Paclitaxel induced hand foot syndrome - A rare case report

Hand-foot syndrome (HFS) is a common complication of several chemotherapy agents. But the incidence of paclitaxel-associated HFS is rare. Here, we present such a rare case of paclitaxel induced HFS in a 70-year-old female with advanced metastatic squamous cell carcinoma of the buccal mucosa. Clinical presentation was of grade 3 severity with blisters formation and ulceration requiring discontinuation of paclitaxel. The intent to present such a rare case is to create awareness about such occurrences while administering paclitaxel and for prompt action; as delay can lead to severe limitations of daily activities of the patient therein hampering the quality of life.