阿佛斯甘酸胆碱在认知障碍矫正中的应用

O. A. Shavlovskaya, I. D. Romanov, I. A. Bokova
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引用次数: 0

摘要

在临床前和临床研究中,阿佛斯甘酸胆碱(CA)已被证明在矫正认知障碍(CI)方面非常有效。CA 的临床效果体现在改善精神活动、集中力、记忆和回忆信息的能力、认知和行为反应、消除情绪不稳定和冷漠等方面。实验研究表明,CA 能有效预防大脑皮层的萎缩性变化。根据几项关于使用 CA 治疗 CI 的研究,可以得出结论,建议口服 CA,剂量为 600 毫克/天,既可作为单一疗法,也可作为慢性脑缺血等脑血管疾病患者复合疗法的一部分。作为阿尔茨海默病 CI 综合疗法的一部分,建议将 1200 毫克/天剂量的 CA 与 10 毫克/天剂量的多奈哌齐联合使用。多项研究表明,CA 对治疗 COVID 后和创伤后 CI 具有疗效。服用 CA 对治疗缺血性中风和短暂性脑缺血发作后的 CI(包括血管性痴呆)也有疗效。服用 CA 还可减轻焦虑和抑郁障碍、虚弱、疼痛症状的严重程度以及协调性的变化。根据 CI 的严重程度,疗程应为 60 至 90 天,随后是长达 2 年的观察阶段。要成功治疗 CA,必须反复进行 CI 治疗。如今,俄罗斯市场上出现了一种新药 Cerpechol(600 毫克/7 毫升),它具有 CA 的所有功效。新药(口服溶液)使用方便,可用于吞咽障碍患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Choline alfoscerate in the correction of cognitive impairment
In preclinical and clinical studies, choline alfoscerate (CA) has proven to be highly effective in the correction of cognitive impairment (CI). The clinical effect of CA is seen in the improvement of mental activity, concentration, ability to remember and recall information, cognitive and behavioural responses, elimination of emotional instability and apathy. Experimental studies have shown the effectiveness of CA in preventing atrophic changes in the cerebral cortex. Based on several studies conducted on the use of CA in the treatment of CI, it can be concluded that oral administration of CA at a dose of 600 mg/day can be recommended both as monotherapy and as part of complex therapy in patients with cerebrovascular diseases such as chronic cerebral ischemia. As part of complex therapy for CI in Alzheimer's disease, a combination of CA at a dose of 1200 mg/day with donepezil at a dose of 10 mg/day may be recommended. Several studies have demonstrated the efficacy of CA in the treatment of post-COVID and post-traumatic CI. The efficacy of CA administration in the treatment of CI (including vascular dementia) following ischemic stroke and transient ischemic attacks has been demonstrated. When CA is taken, there is also a reduction in anxiety and depressive disorders, asthenia, the severity of pain symptoms and changes in coordination. The duration of therapy should be 60 to 90 days, depending on the severity of CI, followed by an observation phase of up to 2 years. For successful treatment with CA, it is necessary to carry out repeated courses of CI treatment. Today, a new drug Cerpechol (600 mg/7 ml) has appeared on the Russian market, which has all the effects of CA. The convenience of the new form (oral solution) makes it possible to use it in patients with swallowing disorders.
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