妊娠糖尿病孕妇血清中心肌营养素-1 浓度的研究

IF 0.7 4区 医学 Q4 OBSTETRICS & GYNECOLOGY
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-08-01 Epub Date: 2023-12-20 DOI:10.1055/a-2210-4215
Yegana Huseynli, İbrahim Kale, Merve Dizdar, Murat Muhcu
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引用次数: 0

摘要

研究目的我们旨在研究妊娠期糖尿病(GDM)孕妇血清中的心肌营养素-1(CT-1)浓度:这项前瞻性非干预性队列研究的对象是 2022 年 10 月至 2023 年 5 月期间前往乌姆拉尼耶培训与研究医院妇产科就诊的 160 名孕妇。GDM组由80名根据75克OGTT确诊为GDM的孕妇组成。对照组由 80 名健康孕妇组成,她们在年龄和体重指数方面与 GDM 组相匹配,且 75g OGTT 结果正常。两组孕妇的血清 CT-1 浓度进行了比较:结果:两组在人口统计学特征和 CT-1 采血孕周方面相似(P>0.05)。GDM组的母体血清CT-1平均浓度为1420.9 pg/ml,而对照组为1455 pg/ml(P=0.738)。当根据参与者的体重指数将 GDM 组和对照组分为正常体重和超重两个亚组时,发现这四个组的血清 CT-1 浓度相似(P=0.084)。将 GDM 组分为单纯饮食组和使用胰岛素调节血糖组两组,并与对照组进行比较,三组的血清 CT-1 浓度也相似(P=0.189):CT-1是一种参与糖代谢调节的脂肪因子,被认为与糖尿病的病理生理学有关。本研究发现,GDM 组与糖耐量正常组的血清 CT-1 浓度相似。CT-1 是否导致 GDM 的发生目前尚不清楚,需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of Serum Cardiotrophin-1 Concentrations in Pregnant Women with Gestational Diabetes Mellitus.

Objective: We aimed to investigate cardiotrophin-1 (CT-1) concentrations in the serum of pregnant women with gestational diabetes mellitus (GDM).

Materials and methods: This prospective non-interventional cohort study was conducted with 160 pregnant women who applied to the Umraniye Training and Research Hospital, Department of Obstetrics and Gynecology between October 2022 and May 2023. The GDM group was formed from 80 pregnant women who were diagnosed with GDM according to the 75-g OGTT. The control group consisted of 80 healthy pregnant women who were matched with the GDM group in terms of age and body mass index and had a normal 75-g OGTT result. Two groups were compared in terms of maternal serum CT-1 concentrations.

Results: Both groups were similar in terms of demographic features and the gestational week at blood sampling for CT-1 (p>0.05 for each). The mean maternal serum CT-1 concentration was found to be 1420.9 pg/ml in the GDM group, while it was determined as 1455 pg/ml in the control group (p=0.738). When the GDM and control groups were divided into two subgroups, normal weight and overweight according to the participants' BMI, serum CT-1 concentrations were found to be similar in these four groups (p=0.084). When the GDM group was divided into two groups of diet-only and the insulin-using group for blood glucose regulation and compared with the control group, the three groups were also similar in terms of serum CT-1 concentrations (p=0.189).

Conclusion: CT-1 is an adipokine involved in the regulation of glucose metabolism and has been suggested to be associated with the pathophysiology of diabetes mellitus. In this study, serum CT-1 concentrations were found to be similar in the group with GDM and the group with normal glucose tolerance. Whether CT-1 contributes to the development of GDM is currently unclear and requires further investigation.

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来源期刊
Zeitschrift fur Geburtshilfe und Neonatologie
Zeitschrift fur Geburtshilfe und Neonatologie OBSTETRICS & GYNECOLOGY-PEDIATRICS
CiteScore
1.10
自引率
0.00%
发文量
166
审稿时长
>12 weeks
期刊介绍: Gynäkologen, Geburtshelfer, Hebammen, Neonatologen, Pädiater
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