作为表观遗传学靶标的 SET 蛋白。

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2024-02-01 Epub Date: 2023-12-22 DOI:10.2217/epi-2023-0297

Gabriel da Silva, Thaís Moré Milan, Pablo Shimaoka Chagas, Glauce Lunardelli Trevisan, Camila Lopes Ferraz, Andréia Machado Leopoldino

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引用次数: 0

摘要

据 NCBI 报道，SET 基因有四个转录本，编码两种同工酶 SET 蛋白。SET 蛋白最著名的功能是抑制蛋白磷酸酶 2A，这是一种肿瘤抑制因子，与不同的生物过程有关。在这篇综述中，我们重点探讨了 SET 与表观遗传机制有关的其他功能，这些功能会影响细胞迁移、细胞周期和细胞凋亡。

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SET protein as an epigenetics target.

The SET gene has four transcripts reported in NCBI, coding two isoforms of SET proteins. The most known function of SET protein is inhibiting protein phosphatase 2A, a tumor suppressor, which has been associated with different biological processes. In this review, our focus was on exploring the other SET functions related to epigenetic mechanisms, which impact cellular migration, cell cycle and apoptosis.

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.