自然杀伤细胞识别 HLA I 类分子。

Reviews in immunogenetics Pub Date : 2000-01-01
A G Brooks, J C Boyington, P D Sun
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引用次数: 0

摘要

人类 NK 细胞表达与 HLA I 类分子相互作用的多种受体。这些受体属于两大蛋白超家族之一,即免疫球蛋白超家族或 C 型凝集素超家族。杀伤细胞免疫球蛋白样受体(KIR)家族主要识别经典的 HLA I 类分子,不同的家族成员与不同的 HLA I 类异型相互作用。KIR2DL2 与其配体 HLA-Cw3 复合物的晶体结构提供了 KIR 与 I 类相互作用的分子细节。该相互作用位点横跨 I 类的α1 和α2 螺旋,KIR 与肽残基 7 和 8 直接接触。KIR2DL2 对 HLA-Cw3 的异型特异性是 KIR 的 Lys44 与 HLA-C 的 Asn80 单氢键作用的结果,因为与 KIR 接触的所有其他 HLA-C 残基都是保守的。凝集素样 CD94/NKG2 受体专门与非经典的 I 类分子 HLA-E 相互作用。细胞表面 HLA-E 的表达依赖于其他 I 类分子的表达,因为它们是正常细胞中 HLA-E 结合肽的主要来源。因此,CD94/NKG2 受体对 HLA-E 的识别允许 NK 细胞间接监测大量 I 类分子的表达。虽然 KIR 和 CD94/NKG2 受体识别配体的分子相互作用可能各不相同,但这两个受体家族对 I 类分子的识别似乎都依赖于肽。这表明,缺乏 I 类分子的细胞,以及用肽负载 I 类分子的能力受损的细胞,将成为 NK 介导的破坏目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Natural killer cell recognition of HLA class I molecules.

Human NK cells express multiple receptors that interact with HLA class I molecules. These receptors belong to one of two major protein superfamilies, the immunoglobulin superfamily or the C type lectin superfamily. The killer cell immunoglobulin-like receptor (KIR) family predominantly recognise classical HLA class I molecules and different family members interact with discrete HLA class I allotypes. The solution of the crystal structure of KIR2DL2 in complex with its ligand, HLA-Cw3 has provided the molecular details of a KIR/class I interaction. The interaction site spans both the alpha1 and alpha2 helices of class I and the KIR makes direct contact with peptide residues 7 and 8. The allotype specificity of KIR2DL2 for HLA-Cw3 is the result of a single hydrogen bond from Lys44 of the KIR to Asn80 of HLA-C as all other HLA-C residues that contact KIR are conserved. The lectin-like CD94/NKG2 receptors specifically interact with the non-classical class I molecule, HLA-E. Cell surface expression of HLA-E is dependent on the expression of other class I molecules as they are the major source of HLA-E binding peptides in normal cells. Consequently recognition of HLA-E by the CD94/NKG2 receptors allows NK cells to indirectly monitor the expression of a broad array of class I molecules. While the molecular interactions underlying ligand recognition by both KIR and CD94/NKG2 receptors are likely to be distinct, recognition of class I by both families of receptors appears peptide dependent. This suggest that cells that lack class I and also those that are impaired in their ability to load class I molecules with peptide will become targets for NK-mediated destruction.

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