5-氟尿嘧啶对男性和女性生殖系统的毒性:叙述性综述。

Ali Tavakoli Pirzaman, Pouyan Ebrahimi, Shahrbanoo Doostmohamadian, Bardia Karim, Darya Almasi, Fatemeh Madani, Ahmadreza Moghadamnia, Sohrab Kazemi
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引用次数: 0

摘要

化疗药物 5-氟尿嘧啶(5FU)常用于治疗各种实体恶性肿瘤,如结直肠癌、胰腺癌、胃癌、乳腺癌和头颈癌。其抗肿瘤作用是通过干扰 RNA 和 DNA 的合成以及抑制恶性和非恶性细胞中的胸苷酸合成酶来实现的。因此,5FU 会对人体重要器官(包括心脏、肝脏、肾脏和生殖系统)产生严重毒性。鉴于5FU诱发的生殖毒性可能会限制该药物的临床应用,本研究旨在讨论5FU诱发生殖毒性的主要部位和机制。首先,我们讨论了 5FU 对男性生殖系统的影响,它导致了曲细精管上皮细胞的损伤和 Sertoli 细胞空泡的形成。虽然在组织病理学层面没有发生明显的变化,但前列腺的重量会减轻。此外,5FU 还会导致精子发生明显异常,包括生精细胞脱落、精子晕形成、多核巨细胞和精子数量减少。最后,在女性中,5FU 引起的生殖毒性的特点是出现闭锁的次级卵泡和前卵泡,生长卵泡数量减少,卵巢重量减轻,成熟度受损。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
5-Flourouracil-induced toxicity in both male and female reproductive systems: A narrative review.

The chemotherapeutic drug 5-flourouracil (5FU) is frequently used to treat a wide range of solid malignant tumors, such as colorectal, pancreatic, gastric, breast, and head and neck cancers. Its antitumoral effects are achieved by interfering with the synthesis of RNA and DNA and by inhibiting thymidylate synthase in both malignant and non-malignant cells. Therefore, it can be responsible for severe toxicities in crucial body organs, including heart, liver, kidney, and reproductive system. Given the fact that 5FU-induced reproductive toxicity may limit the clinical application of this drug, in this study, we aimed to discuss the main locations and mechanisms of the 5FU-induced reproductive toxicity. Initially, we discussed the impact of 5FU on the male reproductive system, which leads to damage of the seminiferous epithelial cells and the development of vacuoles in Sertoli cells. Although no noticeable changes occur at the histopathological level, there is a decrease in the weight of the prostate. Additionally, 5FU causes significant abnormalities in spermatogenesis, including germ cell shedding, spermatid halo formation, polynucleated giant cells, and decreased sperm count. Finally, in females, 5FU-induced reproductive toxicity is characterized by the presence of atretic secondary and antral follicles with reduced numbers of growing follicles, ovarian weight, and maturity impairment.

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