脊髓损伤后盆腔器官传入和传出输入的萌芽。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Shunyi Zhao, Chuanxi Tang, Jeremy Weinberger, Dianshuai Gao, Shaoping Hou
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引用次数: 0

摘要

脊髓损伤(SCI)后,中枢神经系统和周围神经系统都会发生神经可塑性。虽然中枢神经的改变已被广泛研究,但盆腔内脏的传入和传出纤维是否会发生类似的形态学变化,目前还不得而知。利用大鼠脊髓横断模型,我们采用免疫组化方法研究了肾脏、结肠和膀胱的传入和传出神经支配。损伤后约 3-4 周,免疫染色显示酪氨酸羟化酶(TH)标记的节后交感神经纤维和降钙素基因相关肽(CGRP)免疫反应的感觉终端在肾盂和结肠中萌发。从形态上看,萌发的传入或传出突起呈现出杂乱无章的结构。然而,在膀胱中,脊髓损伤大鼠出现了更密集的 CGRP 阳性初级感觉纤维,而 TH 阳性交感传出纤维则没有变化。在膀胱损伤后的肌肉层和固有层观察到大量 CGRP 阳性传入。TH阳性传出输入显示肥大,直径变大,但其神经支配模式保持不变。总之,盆腔器官在脊髓损伤后广泛萌发传入或传出输入,这可能是功能适应或不适应的形态学基础之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sprouting of afferent and efferent inputs to pelvic organs after spinal cord injury.

Neural plasticity occurs within the central and peripheral nervous systems after spinal cord injury (SCI). Although central alterations have extensively been studied, it is largely unknown whether afferent and efferent fibers in pelvic viscera undergo similar morphological changes. Using a rat spinal cord transection model, we conducted immunohistochemistry to investigate afferent and efferent innervations to the kidney, colon, and bladder. Approximately 3-4 weeks after injury, immunostaining demonstrated that tyrosine hydroxylase (TH)-labeled postganglionic sympathetic fibers and calcitonin gene-related peptide (CGRP)-immunoreactive sensory terminals sprout in the renal pelvis and colon. Morphologically, sprouted afferent or efferent projections showed a disorganized structure. In the bladder, however, denser CGRP-positive primary sensory fibers emerged in rats with SCI, whereas TH-positive sympathetic efferent fibers did not change. Numerous CGRP-positive afferents were observed in the muscle layer and the lamina propria of the bladder following SCI. TH-positive efferent inputs displayed hypertrophy with large diameters, but their innervation patterns were sustained. Collectively, afferent or efferent inputs sprout widely in the pelvic organs after SCI, which may be one of the morphological bases underlying functional adaptation or maladaptation.

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CiteScore
7.20
自引率
4.30%
发文量
567
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