Prader-Willi 和 Bardet-Biedl 综合征患儿血清胃泌素和 Glukagon-like Peptid 1 水平。

IF 1.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Doğa Türkkahraman, Suat Tekin, Merve Güllü, Güzin Aykal
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引用次数: 0

摘要

目的:普拉德-威利综合征(Prader-Willi Syndrome,PWS)和巴尔德-比德尔综合征(Bardet-Biedl Syndrome,BBS)是小儿综合肥胖症的常见病因。我们旨在研究胃泌素和类谷草酮肽-1(GLP-1)在普拉德-威利综合征(PWS)和巴尔德-比德尔综合征(BBS)的病理生理学中可能发挥的作用:我们招募了12名PWS患者、12名BBS患者、13名肥胖对照组(OC)和12名瘦弱对照组(LC)。方法:我们招募了12名PWS患者、12名BBS患者、13名肥胖对照组(OC)和12名瘦弱对照组(LC),采用ELISA方法测定空腹血清胃泌素和GLP-1水平:结果:PWS 组的胃泌素水平与 OC 组和 LC 组相比无明显差异,分别为 0.96(0.69-1.15)、0.92(0.72-1.20)和 1.13(0.84-1.29 ng/ml)。同样,与 OC 和 LC 相比,GLP-1 也没有发现明显差异;分别为 1.86(1.5-2.94)、2.24(1.62-2.78)和 2.06(1.8-3.41)纳克/毫升。在 BBS 组中,胃泌素与 OK 组和 SC 组相比无明显差异,分别为 1.05(0.87-1.51)、0.92(0.72-1.20)和 1.13(0.84-1.29)纳克/毫升。同样,与 OC 和 SC 相比,GLP-1 也没有发现明显差异;分别为 2.46(1.91-4.17)、2.24(1.62-2.78)和 2.06(1.8-3.41)纳克/毫升:我们没有发现胃泌素和 GLP-1 在 PWS 和 BBS 肥胖症的发病机制中起明确作用。结论:我们发现胃泌素和 GLP-1 在 PWS 和 BBS 的肥胖症发病机制中没有明确作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum Ghrelin and Glucagon-like Peptide 1 Levels in Children with Prader-Willi and Bardet-Biedl Syndromes

Objective: Prader-Willi syndrome (PWS) and Bardet-Biedl syndrome (BBS) are causes of pediatric syndromic obesity. We aimed to investigate a possible role for ghrelin and glucagon-like peptide-1 (GLP-1) in the pathophysiology of PWS and BBS.

Methods: The study included 12 children with PWS, 12 children with BBS, 13 pediatric obese controls (OC) and 12 pediatric lean controls (LC). Fasting serum ghrelin and GLP-1 levels were measured by ELISA.

Results: In the PWS group, no significant difference was detected for median ghrelin levels when compared with OC and LC, which were 0.96 (0.69-1.15), 0.92 (0.72-1.20) and 1.13 (0.84-1.29) ng/mL, respectively. Similarly, there was no difference in PWS median GLP-1 levels when compared with OC and LC; 1.86 (1.5-2.94), 2.24 (1.62-2.78) and 2.06 (1.8-3.41) ng/mL, respectively. In the BBS group, there was no difference in median ghrelin levels when compared with OC and LC; 1.05 (0.87-1.51), 0.92 (0.72-1.20) and 1.13 (0.84-1.29) ng/mL, respectively. Neither was there a significant difference in median GLP-1 levels; 2.46 (1.91-4.17), 2.24 (1.62-2.78) and 2.06 (1.8-3.41) ng/mL for BBS, OC and LC, respectively.

Conclusion: There were no differences in median fasting ghrelin or GLP-1 levels when comparing patients with PWS and BBS with obese or lean peers. However, similar studies with larger series are needed.

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来源期刊
Journal of Clinical Research in Pediatric Endocrinology
Journal of Clinical Research in Pediatric Endocrinology ENDOCRINOLOGY & METABOLISM-PEDIATRICS
CiteScore
3.60
自引率
5.30%
发文量
73
审稿时长
20 weeks
期刊介绍: The Journal of Clinical Research in Pediatric Endocrinology (JCRPE) publishes original research articles, reviews, short communications, letters, case reports and other special features related to the field of pediatric endocrinology. JCRPE is published in English by the Turkish Pediatric Endocrinology and Diabetes Society quarterly (March, June, September, December). The target audience is physicians, researchers and other healthcare professionals in all areas of pediatric endocrinology.
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