研究黑麦草对氧化钛纳米颗粒治疗小鼠第一代后代睾丸功能的影响。

IF 1.9 Q3 CHEMISTRY, MEDICINAL
Morteza Abouzaripour, Erfan Daneshi, Fariba Amiri, Sherko Naseri, Azra Allahveisi
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引用次数: 0

摘要

目的:纳米粒子包括至少有一个尺寸小于 100 纳米的原生粒子。材料和方法:使用 30 只成年小鼠(10 雄 20 雌)。交配后,怀孕的雌性小鼠被随机分为 4 个研究组(每组 5 只)。从妊娠第 13 天起至分娩,给小鼠服用 TNP 和 NS。分娩后,从每组中挑选 10 只新生雄性小鼠,按照之前的分组(4 组)在标准条件下饲养至青春期。取出每只小鼠的附睾,收集精子用于体外受精评估,收集睾丸用于第一代小鼠体外受精的组织病理学和精子发生:结果:NS组与对照组无明显差异(P>0.05)。结果:NS 组与对照组无明显差异(p>0.05);TNP 组观察到一定程度的上皮溶解,精子活力显著下降(p):本研究发现,NS 对生殖上皮没有破坏作用。然而,NS对TNP引起的小鼠睾丸生精细胞损伤有改善作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the effect of Nigella sativa on the testicular function of first-generation offspring of mice treated with titanium oxide nanoparticles.

Objective: Nanoparticles include primary particles with at least one of their dimensions being less than 100 nm. The goal of this research was to determine the possible protective role of Nigella sativa (NS) against toxic effects mediated by titanium oxide nanoparticle (TNP).

Materials and methods: 30 adult mice (10 males and 20 females) were used. After mating, the pregnant female mice were randomly divided into 4 study groups (n=5 mice in each group). From the 13th day of gestation until delivery, the mice were given TNP and NS. After delivery, 10 newborn male mice were selected from each group and kept under standard conditions until puberty according to the previous grouping (4 groups). The epididymis of each mouse was removed and the sperm was collected for the evaluation of in vitro fertilization and testis for histopathology and spermatogenesis of in vitro fertilization of first-generation mice.

Results: No significant difference was observed between the NS group and the control group (p>0.05). In the TNP, a degree of epithelial lysis and a significant decrease in sperm motility was observed (p<0.05) compared with the control group. In the TNP and NS group, NS had an ameliorating effect on TNP-induced testicular germ cell damage (p<0.05).

Conclusion: In the present study, it was found that NS had no destructive effect on the germinal epithelium. However, NS had an ameliorating effect on TNP-induced testicular germ cell damage in mice.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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