米索前列醇加月见草(Oenothera biennis)和不加月见草(Oenothera biennis)对诱发漏吸流产的影响。

IF 1.9 Q3 CHEMISTRY, MEDICINAL
Mozhgan Mahmoodinasab, Marzeyeh Loripoor, Reza Vazirinejad, Fariba Aminzadeh
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引用次数: 0

摘要

目的确定在以米索前列醇为基础的人工流产方案中添加月见草是否能提高人工流产的成功率:在这项随机临床试验中,148 名被诊断为流产失误并转诊至拉夫萨纳因 Niknafas 医院的妇女被随机分为两组,每组 74 名受试者。干预组在住院前一晚使用 2000 毫克月见草阴道胶囊,而对照组不使用任何药物。两组均在入院后接受初始剂量为 800 μg 的阴道米索前列醇,必要时在三小时后给予下一次剂量:结果:两组在完全流产率、宫颈的粘稠度和扩张程度、从首次服用米索前列醇到胎儿排出的时间、米索前列醇的剂量以及住院期间阴道出血量方面均有显著差异。他们在刮宫、住院时间和副作用方面没有明显差异。两组的平均疼痛评分无明显差异,但干预组的评分较低(P>0.05):结论:与单独使用米索前列醇相比,在使用米索前列醇之前先使用月见草阴道制剂能更有效地治疗漏流。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of misoprostol with and without evening primrose (Oenothera biennis) on induction of missed abortion.

Objective: To determine whether addition of evening primrose to a misoprostol-based abortion regimen can increase the success of abortion.

Materials and methods: In this randomized clinical trial., 148 women referring to Niknafas Hospital in Rafsanajn with diagnosis of missed abortion were randomly allocated into two 74-subject groups. The intervention group used 2000 mg vaginal evening primrose capsules the night before the hospitalization, while the control group did not receive any medication. Both groups received an initial dose of 800 μg of vaginal misoprostol after admission and the next dose was given three hours later if necessary.

Results: The two groups had significant differences in terms of full abortion, consistency and dilatation of cervix, duration between the first dose of misoprostol until the ejection of fetus, the misoprostol dose administered, and the level of vaginal bleeding during the hospitalization. They had no significant differences regarding curettage, duration of hospitalization, or side effects. The mean pain score had no significant difference between the two groups, though the score was lower in the intervention group (p>0.05).

Conclusion: Administration of vaginal evening primrose before vaginal misoprostol was found to be more effective compared to misoprostol alone in missed abortion.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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