六味地黄丸通过YAP-自噬轴缓解骨髓间充质干细胞（BMSC）衰老，从而减轻卵巢切除术引起的骨质流失

IF 3.9 3区医学 Q1 MEDICAL LABORATORY TECHNOLOGY

Pharmaceutical Biology Pub Date : 2023-12-19 DOI:10.1080/13880209.2023.2291675

Bing Liang, Xiongbin Chen, Min Li, Lingling Zhang, Xia Yang, Liangqin Shi, Yanju Gong, Yuanyuan Gong, Huan Xu, Xiao Wu, Zhong Jin, Yanru Wang, Luwei Liu, Xiaohong Yi, Lushuang Xie, Hua Zhong, Chongyang Shen, Yong Wang, Lan Yang

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引用次数: 0

摘要

为了探讨六味地黄丸对绝经后骨质疏松症（PMOP）的影响和作用机制，研究人员将48只雌性Sprague-Dawley大鼠分成两组，每组10只，每组3只。

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Liuwei Dihuang pills attenuate ovariectomy-induced bone loss by alleviating bone marrow mesenchymal stem cell (BMSC) senescence via the Yes-associated protein (YAP)-autophagy axis

Liuwei Dihuang pill (LWDH) has been used to treat postmenopausal osteoporosis (PMOP).To explore the effects and mechanisms of action of LWDH in PMOP.Forty-eight female Sprague-Dawley rats were divi...

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来源期刊

Pharmaceutical Biology 医学-药学

CiteScore

6.70

自引率

2.60%

发文量

191

审稿时长

1 months

期刊介绍： Pharmaceutical Biology will publish manuscripts describing the discovery, methods for discovery, description, analysis characterization, and production/isolation (including sources and surveys) of biologically-active chemicals or other substances, drugs, pharmaceutical products, or preparations utilized in systems of traditional medicine. Topics may generally encompass any facet of natural product research related to pharmaceutical biology. Papers dealing with agents or topics related to natural product drugs are also appropriate (e.g., semi-synthetic derivatives). Manuscripts will be published as reviews, perspectives, regular research articles, and short communications. The primary criteria for acceptance and publication are scientific rigor and potential to advance the field.