小儿急性白血病 HLA 匹配非亲缘供体造血干细胞移植后，供体抑制性 KIR 增加与 GVHD 减少和存活率提高有关

medRxiv - Transplantation Pub Date : 2023-12-15 DOI:10.1101/2023.12.14.23299955

Elizabeth Krieger, Rehan Qayyum, Amir Toor

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引用次数: 0

摘要

杀伤性免疫球蛋白样受体（KIR）和 KIR 配体（KIRL）的相互作用在造血干细胞移植（HCT）后自然杀伤细胞介导的效应中起着重要作用。先前的研究表明，考虑已知的 KIR-KIRL 相互作用可识别出在成人移植环境中具有最佳 NK 细胞介导异体活性的捐献者。

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Increased Donor Inhibitory KIR Are Associated with Reduced GVHD and Improved Survival Following HLA Matched Unrelated Donor HCT in Pediatric Acute Leukemia

Killer immunoglobulin-like receptor (KIR) and KIR-ligand (KIRL) interactions play an important role in natural killer cell-mediated effects after hematopoietic stem cell transplantation (HCT). Previous work has shown that accounting for known KIR-KIRL interactions may identify donors with optimal NK cell-mediated alloreactivity in the adult transplant setting.

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medRxiv - Transplantation

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