Yun Yan, Karunaratne Tennekoon, Audrey Eubanks, Anam Herekar, Dhanush Shimoga, Deepak Ayyala, Colin McLeod, Julie A. Kurek, John C. Morgan, Satish S. C. Rao, Amol Sharma
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Evaluation of bidirectional gut-brain axis and anorectal function in Parkinson's disease with constipation
Parkinson's disease (PD) is a neurodegenerative movement disorder with prodromal and highly prevalent gastrointestinal (GI) symptoms, especially constipation. Although PD models suggest gut-brain axis dysfunction, the mechanistic underpinnings and their correlation with GI symptoms are poorly understood.