Nathan N O'Hara, Robert V O'Toole, Katherine P Frey, Renan C Castillo, Joseph Cuschieri, Elliott R Haut, Gerard P Slobogean, Reza Firoozabadi, Ashley Christmas, William T Obremskey, Anthony R Carlini, Greg Gaski, Matthew E Kutcher, Debra Marvel, Deborah M Stein
{"title":"骨科创伤患者服用阿司匹林与低分子量肝素的风险分层血栓预防效果：PREVENT CLOT 试验的二次分析。","authors":"Nathan N O'Hara, Robert V O'Toole, Katherine P Frey, Renan C Castillo, Joseph Cuschieri, Elliott R Haut, Gerard P Slobogean, Reza Firoozabadi, Ashley Christmas, William T Obremskey, Anthony R Carlini, Greg Gaski, Matthew E Kutcher, Debra Marvel, Deborah M Stein","doi":"10.1097/ta.0000000000004226","DOIUrl":null,"url":null,"abstract":"The PREVENT CLOT trial concluded that thromboprophylaxis with aspirin was noninferior to low-molecular-weight heparin (LMWH) in preventing death after orthopaedic trauma. However, it was unclear if these results applied to patients at highest risk of thrombosis. Therefore, we assessed if the effect of aspirin versus LMWH differed based on patients' baseline risk of venous thromboembolism (VTE).","PeriodicalId":501845,"journal":{"name":"The Journal of Trauma and Acute Care Surgery","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Risk-stratified thromboprophylaxis effects of aspirin versus low-molecular-weight heparin in orthopaedic trauma patients: a secondary analysis of the PREVENT CLOT trial.\",\"authors\":\"Nathan N O'Hara, Robert V O'Toole, Katherine P Frey, Renan C Castillo, Joseph Cuschieri, Elliott R Haut, Gerard P Slobogean, Reza Firoozabadi, Ashley Christmas, William T Obremskey, Anthony R Carlini, Greg Gaski, Matthew E Kutcher, Debra Marvel, Deborah M Stein\",\"doi\":\"10.1097/ta.0000000000004226\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The PREVENT CLOT trial concluded that thromboprophylaxis with aspirin was noninferior to low-molecular-weight heparin (LMWH) in preventing death after orthopaedic trauma. However, it was unclear if these results applied to patients at highest risk of thrombosis. Therefore, we assessed if the effect of aspirin versus LMWH differed based on patients' baseline risk of venous thromboembolism (VTE).\",\"PeriodicalId\":501845,\"journal\":{\"name\":\"The Journal of Trauma and Acute Care Surgery\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Trauma and Acute Care Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/ta.0000000000004226\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Trauma and Acute Care Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/ta.0000000000004226","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Risk-stratified thromboprophylaxis effects of aspirin versus low-molecular-weight heparin in orthopaedic trauma patients: a secondary analysis of the PREVENT CLOT trial.
The PREVENT CLOT trial concluded that thromboprophylaxis with aspirin was noninferior to low-molecular-weight heparin (LMWH) in preventing death after orthopaedic trauma. However, it was unclear if these results applied to patients at highest risk of thrombosis. Therefore, we assessed if the effect of aspirin versus LMWH differed based on patients' baseline risk of venous thromboembolism (VTE).
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