乙太溶剂中氢化镁介导的 1,1-二芳基烯烃氢烷基化反应

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-12-14 DOI:10.1002/hlca.202300212

Nattawadee Chaisan, Eugene Yew Kun Tan, Shunsuke Chiba

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引用次数: 0

摘要

利用碘化镁（MgI2）与氢化钠（NaH）在乙醚溶剂中进行溶解热处理而就地生成的氢化镁（MgH2），开发出了一种 1,1-二芳基烯烃的氢烷基化方法。该工艺通过 MgH2 对 1,1-二芳基烯烃进行水镁化反应来生成 1,1-二芳基镁，然后立即用乙醚溶剂对其进行烷基化反应，从而在水烷基化产物中形成二芳基季碳中心。

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Hydroalkylation of 1,1-Diarylalkenes Mediated by Magnesium Hydride in Ethereal Solvents

A method for the hydroalkylation of 1,1-diarylalkenes has been developed using magnesium hydride (MgH₂) generated in situ by the solvothermal treatment of magnesium iodide (MgI₂) with sodium hydride (NaH) in ethereal solvents. The process is initiated by the hydromagnesiation of 1,1-diarylalkenes with MgH₂ to generate 1,1-diarylethylmagnesium species, which are immediately alkylated with ethereal solvents to construct a diaryl quaternary carbon center in the hydroalkylation products.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.