聚-L-乳酸对经紫外线 B 线照射的培养脂肪细胞中脂肪生成和胶原蛋白基因表达的影响

IF 1.5 4区医学 Q3 DERMATOLOGY

Annals of Dermatology Pub Date : 2023-12-13 DOI:10.5021/ad.22.177

Hyun-Wook Kim, Yun-A Jung, Ji-Min Yun, Yura Kim, Sung-Ae Kim, Seong-Il Suh, Young-Wook Ryoo

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引用次数: 0

摘要

聚左乳酸（PLLA）是一种人工合成、生物相容性好、可生物降解的聚合物，已被安全地用于多种临床应用。最近，聚乳酸被广泛应用于皮肤科领域，治疗皮肤老化产生的皱纹。据报道，PLLA 可直接作用于真皮成纤维细胞，显著增加 I 型胶原蛋白的表达。然而，人们对 PLLA 对脂肪细胞的影响知之甚少。

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Effects of Poly-L-Lactic Acid on Adipogenesis and Collagen Gene Expression in Cultured Adipocytes Irradiated with Ultraviolet B Rays.

Poly-L-lactic acid (PLLA), a synthetic, biocompatible, and biodegradable polymer, has been safely used in several clinical applications. Recently, PLLA has been widely used in the field of dermatology to treat wrinkles in aging skin. Reportedly, PLLA directly acts on dermal fibroblasts causing a significant increase in the expression of type I collagen. However, little is known about the effect of PLLA on adipocytes.

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来源期刊

Annals of Dermatology 医学-皮肤病学

CiteScore

1.60

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Annals of Dermatology (Ann Dermatol) is the official peer-reviewed publication of the Korean Dermatological Association and the Korean Society for Investigative Dermatology. Since 1989, Ann Dermatol has contributed as a platform for communicating the latest research outcome and recent trend of dermatology in Korea and all over the world. Ann Dermatol seeks for ameliorated understanding of skin and skin-related disease for clinicians and researchers. Ann Dermatol deals with diverse skin-related topics from laboratory investigations to clinical outcomes and invites review articles, original articles, case reports, brief reports and items of correspondence. Ann Dermatol is interested in contributions from all countries in which good and advanced research is carried out. Ann Dermatol willingly recruits well-organized and significant manuscripts with proper scope throughout the world.