用于水凝胶多结构成型和细胞打印的新型便携式原位打印机

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL
Huazhen Liu, Yi Zhang, Zhian Jian, Chuang Gao, Chunxiang Lu, Qiqi Dai, Hao Qiao, Yuanyuan Liu
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引用次数: 0

摘要

皮肤病变不仅会破坏外观和屏障功能,还会导致严重的微生物感染和免疫炎症反应,严重影响身心健康。原位打印涉及生物墨水的直接沉积,以在临床环境中创建或修复受损的组织或器官。在本研究中,我们设计并制作了一种新型便携式原位打印机。这种手持式仪器具有优异的打印性能,允许水凝胶根据特定要求在表面上进行图案和模塑。通过利用高粘度和低粘度的双组分水凝胶共打印方法,我们实现了使用低粘度水凝胶的原位细胞负载打印。这证明了该装置在维持细胞活力和实现水凝胶结构方面的优势。这种方法为有效封装活性成分(如药物、蛋白质和细胞)开辟了可能性,使水凝胶的宏观和微观结构可控。这一突破性发现突出了我们的技术方法在皮肤治疗和伤口修复方面的潜力,通过动态适应和调节微环境,结合水凝胶支架和细胞修复动力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A novel portable in situ printer for hydrogel multi-structure molding and cell printing
Skin lesions not only disrupt appearance and barrier functionality but also lead to severe microbial infections and immune-inflammatory responses, seriously affect physical and mental health. In situ printing involves the direct deposition of bio-ink to create or repair damaged tissues or organs within a clinical setting. In this study, we designed and fabricated a novel portable in situ printer. This handheld instrument exhibits excellent printing performance, allowing hydrogels to be patterned and molded on surfaces according to specific requirements. By utilizing a dual-component hydrogels co-printing approach with high and low viscosities, we achieved in situ cell-laden printing using low-viscosity hydrogel. This demonstrates the advantages of the device in maintaining cell viability and achieving hydrogel structuring. This approach opens up the possibilities for the efficient encapsulation of active components such as drugs, proteins, and cells, enabling controlled macro- and micro-structuring of hydrogels. This breakthrough finding highlights the potential of our technical approach in dermatological treatment and wound repair, by dynamically adapting and regulating microenvironments in conjunction with hydrogel scaffolds and cell reparative impetus.
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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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