抗蛋白 Z 抗体的最新进展

Tiffany Pascreau, Sara Zia-Chahabi, T. Andriamandimbisoa, Marc Vasse
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引用次数: 0

摘要

蛋白Z (PZ)是一种维生素k依赖蛋白,作为PZ依赖蛋白酶抑制剂抑制激活因子X的辅助因子,PZ依赖蛋白酶抑制剂是蛇形蛋白超家族的一种抗凝血蛋白。PZ抗体(aPZ-Abs)的存在首次被描述为与习惯性抗磷脂/抗辅助因子抗体无关的原因不明的反复胚胎丢失、先兆子痫或胎儿死亡的妇女。其他研究表明,aPZ-Ab可能与胎龄小的出生体重有关。这些抗体的作用机制尚不清楚。此时,即使在狼疮抗凝或抗心磷脂抗体患者中也经常观察到aPZ-Abs,但没有证据表明aPZ-Abs会增加全身静脉或动脉血栓形成的风险。各种已发表的研究的比较表明,表明产科风险的阈值没有明确定义。目前尚不清楚是否有一种同型免疫球蛋白(G或M,或两者都有)特别与某些产科症状有关,或者这些抗体在一段时间内持续存在,或者可能由传染病引起。因此,检测这些抗体不是常规的保证,应该只在随机临床试验中进行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An update on anti-protein Z antibodies
Protein Z (PZ) is a vitamin K-dependent protein that acts as a cofactor for the inhibition of activated factor X by the PZ-dependent protease inhibitor, an anticoagulant protein of the serpin superfamily. The presence of antibodies against PZ (aPZ-Abs) was first described in women with unexplained recurrent embryo loss, pre-eclampsia, or foetal death, independently from habitual antiphospholipid/anti-cofactor antibodies. Other studies suggested that aPZ-Ab could be associated with a small birthweight for the gestational age. The mechanism of action of these antibodies is not yet understood. At this time, even aPZ-Abs are frequently observed in patients with lupus anticoagulant or anticardiolipin antibodies, there is no evidence that aPZ-Abs increase systemic venous or arterial thrombotic risk. The comparison of the various published studies shows that the threshold suggesting an obstetric risk is not clearly defined. At present, it is not known whether one isotype of immunoglobulin (G or M, or both) is particularly involved in certain obstetric manifestations, or these antibodies persist during time, or can be induced by infectious diseases. Consequently, detection of these antibodies is not routinely warranted and should only be performed in randomized clinical trials.
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