血小板衍生生物材料对骨质疏松症的潜在治疗效果:当前证据综述

IF 3 Q3 MATERIALS SCIENCE, BIOMATERIALS
Mohammad Amin Amiri, Nima Farshidfar, R. Miron, Arkadiusz Dziedzic, S. Hamedani, Sajad Daneshi, L. Tayebi
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引用次数: 0

摘要

骨质疏松症是一种影响骨骼系统的慢性多因素疾病,导致骨骼微观结构恶化,骨折风险增加。血小板衍生生物材料(PDBs),即所谓的血小板浓缩物,如富血小板血浆(PRP)和富血小板纤维蛋白(PRF),已显示出通过解决微结构损伤来改善骨愈合的潜力。虽然给药血小板浓缩物在骨再生方面取得了积极的结果,但在临床环境中给药的最佳方法仍然存在争议。本综述旨在探讨全身和局部应用PRP/PRF治疗骨质疏松症患者的各种骨缺损和急性骨折。此外,将PRP/PRF与干细胞或骨诱导和骨传导生物材料结合在骨质疏松动物模型中显示出恢复骨微结构特性,治疗骨缺损和改善种植体骨整合的前景。本文回顾了体外和体内研究的结果,为血小板浓缩物如何支持骨质疏松性骨折愈合过程提供了详细的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence
Osteoporosis is a chronic multifactorial condition that affects the skeletal system, leading to the deterioration of bone microstructure and an increased risk of bone fracture. Platelet-derived biomaterials (PDBs), so-called platelet concentrates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have shown potential for improving bone healing by addressing microstructural impairment. While the administration of platelet concentrates has yielded positive results in bone regeneration, the optimal method for its administration in the clinical setting is still debatable. This comprehensive review aims to explore the systemic and local use of PRP/PRF for treating various bone defects and acute fractures in patients with osteoporosis. Furthermore, combining PRP/PRF with stem cells or osteoinductive and osteoconductive biomaterials has shown promise in restoring bone microstructural properties, treating bony defects, and improving implant osseointegration in osteoporotic animal models. Here, reviewing the results of in vitro and in vivo studies, this comprehensive evaluation provides a detailed mechanism for how platelet concentrates may support the healing process of osteoporotic bone fractures.
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来源期刊
International Journal of Biomaterials
International Journal of Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
4.30
自引率
3.20%
发文量
50
审稿时长
21 weeks
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