{"title":"前列腺素类似物与含 1%布林佐胺和 0.5%马来酸噻吗洛尔的固定剂量复方药物疗效的比较评估(实验研究)","authors":"Javadova G.Ch","doi":"10.53432/2078-4104-2023-22-4-45-50","DOIUrl":null,"url":null,"abstract":"PURPOSE. Comparative evaluation of anti-hypertensive effectiveness of tafluprost 0.0015% (Taflotan), and a fixed-combination of benzolamide 1% and timolol maleate 0.5% (Azarga) preparation in an experimental animal model with artificially induced steroidal ophthalmic hypertension.METHODS. The study experiments were performed on 30 sexually mature Chinchilla rabbits (60 eyes) with steroid-induced glaucoma modeled by ocular instillations of dexamethasone.The animals were divided into 3 groups each consisting of 10 rabbits. The first group was the controls that were divided into two subgroups; they were instilled dexamethasone 0.1% two drops per day into the right eye (the left eye remained as control) for 20 days in subgroup 1, and for 30 days in subgroup 2.The animals in group 2 received Azarga, group 3 — Taflotan. Animals of group 2 and 3 were divided into three subgroups: in subgroup 1 the animals were instilled the studied drugs for 10 days, in subgroup 2 — for 20 days, in subgroup 3 — for 30 days.RESULTS. Both drugs reduced the intraocular pressure down to the reference range, i.e. 18–25 mm Hg. Animals that received instillations of Taflotan achieved the refe rence range values after 10 days, while the animals receiving Azarga — after 20 days.CONCLUSIONS. Under the conditions of steroidal ophthalmic hypertension, instillations of both Azarga and Taflotan yield satisfactory results in terms of IOP reduction. The use of Taflotan allowed achieving the reference range values after 10 days, Azarga — after 20 days. Taking into account the ease of administration of Taflotan, it can be recommended as the most convenient and effective drug in terms of reducing intraocular pressure.","PeriodicalId":129515,"journal":{"name":"National Journal glaucoma","volume":"3 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative evaluation of the effectiveness of a prostaglandin analogue and fixed-dose combination drug containing brinzolamide 1% and timolol maleate 0.5% (an experimental study)\",\"authors\":\"Javadova G.Ch\",\"doi\":\"10.53432/2078-4104-2023-22-4-45-50\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"PURPOSE. Comparative evaluation of anti-hypertensive effectiveness of tafluprost 0.0015% (Taflotan), and a fixed-combination of benzolamide 1% and timolol maleate 0.5% (Azarga) preparation in an experimental animal model with artificially induced steroidal ophthalmic hypertension.METHODS. The study experiments were performed on 30 sexually mature Chinchilla rabbits (60 eyes) with steroid-induced glaucoma modeled by ocular instillations of dexamethasone.The animals were divided into 3 groups each consisting of 10 rabbits. The first group was the controls that were divided into two subgroups; they were instilled dexamethasone 0.1% two drops per day into the right eye (the left eye remained as control) for 20 days in subgroup 1, and for 30 days in subgroup 2.The animals in group 2 received Azarga, group 3 — Taflotan. Animals of group 2 and 3 were divided into three subgroups: in subgroup 1 the animals were instilled the studied drugs for 10 days, in subgroup 2 — for 20 days, in subgroup 3 — for 30 days.RESULTS. Both drugs reduced the intraocular pressure down to the reference range, i.e. 18–25 mm Hg. Animals that received instillations of Taflotan achieved the refe rence range values after 10 days, while the animals receiving Azarga — after 20 days.CONCLUSIONS. Under the conditions of steroidal ophthalmic hypertension, instillations of both Azarga and Taflotan yield satisfactory results in terms of IOP reduction. The use of Taflotan allowed achieving the reference range values after 10 days, Azarga — after 20 days. Taking into account the ease of administration of Taflotan, it can be recommended as the most convenient and effective drug in terms of reducing intraocular pressure.\",\"PeriodicalId\":129515,\"journal\":{\"name\":\"National Journal glaucoma\",\"volume\":\"3 5\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"National Journal glaucoma\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.53432/2078-4104-2023-22-4-45-50\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"National Journal glaucoma","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53432/2078-4104-2023-22-4-45-50","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的。对比评价0.0015%他氟前列素(他氟坦)与1%苯并胺与0.5%马来酸替马洛尔(阿扎尔加)固定联合用药在人工甾体性眼性高血压实验动物模型中的降压效果。本研究以30只性成熟鼠(60眼)为实验对象,采用眼内注射地塞米松的方法建立类固醇性青光眼模型。实验动物分为3组,每组10只。第一组是对照组,分为两个亚组;第1亚组为右眼滴注0.1%地塞米松,每天2滴(左眼为对照),连续20天,第2亚组为30天。第2组给予阿扎尔加,第3组给予塔夫罗坦。将第2、3组动物分为3个亚组:第1亚组灌胃研究药物10 d,第2亚组灌胃研究药物20 d,第3亚组灌胃研究药物30 d。两种药物均可使眼压降至参考范围,即18-25 mm Hg,滴入Taflotan的动物在10天后可达到参考值,而滴入Azarga -的动物在20天后可达到参考值。在甾体性眼压升高的情况下,滴注Azarga和Taflotan均可获得满意的IOP降低效果。使用Taflotan可以在10天后达到参考范围值,Azarga -在20天后。考虑到他洛坦易于给药,在降低眼压方面,他洛坦可被推荐为最方便和有效的药物。
Comparative evaluation of the effectiveness of a prostaglandin analogue and fixed-dose combination drug containing brinzolamide 1% and timolol maleate 0.5% (an experimental study)
PURPOSE. Comparative evaluation of anti-hypertensive effectiveness of tafluprost 0.0015% (Taflotan), and a fixed-combination of benzolamide 1% and timolol maleate 0.5% (Azarga) preparation in an experimental animal model with artificially induced steroidal ophthalmic hypertension.METHODS. The study experiments were performed on 30 sexually mature Chinchilla rabbits (60 eyes) with steroid-induced glaucoma modeled by ocular instillations of dexamethasone.The animals were divided into 3 groups each consisting of 10 rabbits. The first group was the controls that were divided into two subgroups; they were instilled dexamethasone 0.1% two drops per day into the right eye (the left eye remained as control) for 20 days in subgroup 1, and for 30 days in subgroup 2.The animals in group 2 received Azarga, group 3 — Taflotan. Animals of group 2 and 3 were divided into three subgroups: in subgroup 1 the animals were instilled the studied drugs for 10 days, in subgroup 2 — for 20 days, in subgroup 3 — for 30 days.RESULTS. Both drugs reduced the intraocular pressure down to the reference range, i.e. 18–25 mm Hg. Animals that received instillations of Taflotan achieved the refe rence range values after 10 days, while the animals receiving Azarga — after 20 days.CONCLUSIONS. Under the conditions of steroidal ophthalmic hypertension, instillations of both Azarga and Taflotan yield satisfactory results in terms of IOP reduction. The use of Taflotan allowed achieving the reference range values after 10 days, Azarga — after 20 days. Taking into account the ease of administration of Taflotan, it can be recommended as the most convenient and effective drug in terms of reducing intraocular pressure.