抗体通过 PIGR 介导的转囊作用靶向细胞内肿瘤驱动因子

IF 5 3区 医学 Q1 GENETICS & HEREDITY
Subir Biswas, Carmen M. Anadon, Jose R. Conejo-Garcia
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引用次数: 0

摘要

单克隆抗体彻底改变了癌症和自身免疫疾病患者的治疗方式,是当代药物开发的最前沿。然而,由于抗体体积较大,无法有效渗透到细胞质中,因此传统上认为抗体无法有效靶向细胞内抗原。然而,人们很早就知道,IgG 可通过与 FcRn 结合和内泌体的胞内转运穿过胎盘,这种现象被称为转胞吐。此外,二聚体 IgA 和五聚体 IgM 也以聚合免疫球蛋白受体(PIGR)依赖的方式通过粘膜细胞进行定向转运。这一复杂的过程不仅能将这些免疫球蛋白转运到粘膜位置的管腔侧,还能中和已经感染上皮细胞的病毒[1]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Antibodies target intracellular oncodrivers through PIGR-mediated transcytosis

Antibodies target intracellular oncodrivers through PIGR-mediated transcytosis

Antibodies target intracellular oncodrivers through PIGR-mediated transcytosis
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来源期刊
Genes and immunity
Genes and immunity 医学-免疫学
CiteScore
8.90
自引率
4.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.
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