与青少年系统性红斑狼疮相关的神经精神表现:以早期诊断为重点的概述

IF 1.4 4区 医学 Q4 CLINICAL NEUROLOGY
Anna Nikolaidou , Ioannis Beis , Pinelopi Dragoumi , Dimitrios Zafeiriou
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引用次数: 0

摘要

幼年系统性红斑狼疮(jSLE)是一种慢性多系统炎症性疾病,在16岁前发病,病程为缓解-复发。儿童的临床表现是多方面的,最常见的症状包括体质、血液学、皮肤、肾脏和神经精神症状。神经精神症状的表现范围很广,约有14-95%的jSLE患者会受到影响。它们与高发病率和高死亡率有关,尤其是在年轻患者中。头痛、癫痫发作、认知功能障碍和情绪障碍是最常见的神经精神症状。其病理生理机制相当复杂,尚未得到充分研究,而自身抗体是研究的重点。神经精神系统性红斑狼疮的诊断仍具有挑战性和排除性。在这篇文章中,我们回顾了与jSLE相关的临床神经精神表现,目的是为患有该病的儿童和青少年提供早期诊断和及时治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuropsychiatric manifestations associated with Juvenile Systemic Lupus Erythematosus: An overview focusing on early diagnosis

Juvenile systemic lupus erythematosus (jSLE) is a chronic multisystem inflammatory disease that manifests before the age of 16 years, following a remitting - relapsing course. The clinical presentation in children is multifaceted, most commonly including constitutional, hematological, cutaneous, renal, and neuropsychiatric symptoms. Neuropsychiatric manifestations range widely, affecting approximately 14–95 % of jSLE patients. They are associated with high morbidity and mortality, particularly at a younger age. Headaches, seizures, cognitive dysfunction, and mood disorders are the most frequent neuropsychiatric manifestations. The pathophysiological mechanism is quite complex and has not yet been fully investigated, with autoantibodies being the focus of research. The diagnosis of neuropsychiatric jSLE remains challenging and exclusionary. In this article we review the clinical neuropsychiatric manifestations associated with jSLE with the aim that early diagnosis and prompt treatment is achieved in children and adolescents with the disease.

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来源期刊
Brain & Development
Brain & Development 医学-临床神经学
CiteScore
3.60
自引率
0.00%
发文量
153
审稿时长
50 days
期刊介绍: Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience. The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.
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