先兆子痫和妊娠糖尿病患者胎盘和外周血的形态功能和分子变化

Q3 Agricultural and Biological Sciences

Doklady Biological Sciences Pub Date : 2023-12-08 DOI:10.1134/s0012496623700722

K. A. Artemieva, Yu. V. Stepanova, I. I. Stepanova, M. V. Shamarakova, N. B. Tikhonova, N. V. Nizyaeva, S. G. Tsakhilova, L. M. Mikhaleva

{"title":"先兆子痫和妊娠糖尿病患者胎盘和外周血的形态功能和分子变化","authors":"K. A. Artemieva, Yu. V. Stepanova, I. I. Stepanova, M. V. Shamarakova, N. B. Tikhonova, N. V. Nizyaeva, S. G. Tsakhilova, L. M. Mikhaleva","doi":"10.1134/s0012496623700722","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors. Although GDM is associated with PE, the exact mechanism underlying the association is unclear. The objective of this work was to study the morphofunctional and molecular changes in the placenta and peripheral blood in PE and GDM. Local and systemic changes in the production of several placental proteins were assessed along with markers of inflammation and metabolic disorders. Expression of placental lactogen, trophoblastic β1-glycoprotein, placental alpha-1-microglobulin, and proteinase 3 in villi was found to change in complicated pregnancy groups. Similarity of underlying pathogenic mechanisms was demonstrated for PE and GDM.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":"76 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Morfofunctional and Molecular Changes in Placenta and Peripheral Blood in Preeclampsia and Gestational Diabetes Mellitus\",\"authors\":\"K. A. Artemieva, Yu. V. Stepanova, I. I. Stepanova, M. V. Shamarakova, N. B. Tikhonova, N. V. Nizyaeva, S. G. Tsakhilova, L. M. Mikhaleva\",\"doi\":\"10.1134/s0012496623700722\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors. Although GDM is associated with PE, the exact mechanism underlying the association is unclear. The objective of this work was to study the morphofunctional and molecular changes in the placenta and peripheral blood in PE and GDM. Local and systemic changes in the production of several placental proteins were assessed along with markers of inflammation and metabolic disorders. Expression of placental lactogen, trophoblastic β1-glycoprotein, placental alpha-1-microglobulin, and proteinase 3 in villi was found to change in complicated pregnancy groups. Similarity of underlying pathogenic mechanisms was demonstrated for PE and GDM.</p>\",\"PeriodicalId\":11351,\"journal\":{\"name\":\"Doklady Biological Sciences\",\"volume\":\"76 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Doklady Biological Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1134/s0012496623700722\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Doklady Biological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s0012496623700722","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}

引用次数: 0

摘要

摘要妊娠期糖尿病（GDM）和子痫前期（PE）是常见的妊娠并发症，具有相似的风险因素。虽然 GDM 与子痫前期相关，但其确切的关联机制尚不清楚。这项工作的目的是研究 PE 和 GDM 中胎盘和外周血的形态功能和分子变化。在评估炎症和代谢紊乱标志物的同时，还评估了几种胎盘蛋白生成的局部和全身变化。在复杂妊娠组中，胎盘泌乳素、滋养层β1-糖蛋白、胎盘α-1-微球蛋白和蛋白酶3在绒毛中的表达发生了变化。PE和GDM的潜在致病机制相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Morfofunctional and Molecular Changes in Placenta and Peripheral Blood in Preeclampsia and Gestational Diabetes Mellitus

查看原文本刊更多论文

Morfofunctional and Molecular Changes in Placenta and Peripheral Blood in Preeclampsia and Gestational Diabetes Mellitus

Abstract

Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors. Although GDM is associated with PE, the exact mechanism underlying the association is unclear. The objective of this work was to study the morphofunctional and molecular changes in the placenta and peripheral blood in PE and GDM. Local and systemic changes in the production of several placental proteins were assessed along with markers of inflammation and metabolic disorders. Expression of placental lactogen, trophoblastic β1-glycoprotein, placental alpha-1-microglobulin, and proteinase 3 in villi was found to change in complicated pregnancy groups. Similarity of underlying pathogenic mechanisms was demonstrated for PE and GDM.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Doklady Biological Sciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Doklady Biological Sciences is a journal that publishes new research in biological sciences of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.