接触金属加工液与非酒精性脂肪肝之间的关系

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Weiling Chan, Geyang Li, Li Zhou, Jin Wang, Lin Song, Lejia Zhu, Lan Lin, Beining Wu, Jing Xiao, Yulong Lian
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引用次数: 0

摘要

目的 以前从未探讨过金属加工液(MWF)与非酒精性脂肪肝(NAFLD)之间的关系。方法 2020年,我们从无锡一家计算机数控加工厂随机抽取了2079名员工进行问卷调查,并在无锡市第八人民医院附属分院进行了职业健康检查。采用美国国家职业安全与健康研究所(NIOSH)的 5524 方法在工厂内采集 MWF 样本。非酒精性脂肪肝的定义是肝脏脂肪变性指数(HSI)≥36,且无明显饮酒。采用逻辑回归分析了非酒精性脂肪肝与 MWF 之间的关系,并使用 R 软件计算了每日暴露阈值。与对照组相比,暴露于MWF的工人患非酒精性脂肪肝的OR值为1.42(95% CI:1.04-1.95)。非酒精性脂肪肝风险的增加与剂量的增加有关。MWFs的日暴露剂量阈值为6.54毫克/立方米(OR = 2.09,95% CI:1.24-3.52)。随着接触浓度的升高,非酒精性脂肪肝的发病率也随之升高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Relationship between exposure to metalworking fluids and nonalcoholic fatty liver disease

Relationship between exposure to metalworking fluids and nonalcoholic fatty liver disease

Objective

The relationship between metalworking fluids (MWFs) and nonalcoholic fatty liver disease (NAFLD) has not been previously explored. We aim to investigate the relationship between occupational exposure to MWFs and the prevalence of NAFLD and to determine the cumulative exposure threshold per day.

Methods

In 2020, 2079 employees were selected randomly from one computer numerical control machining factory in Wuxi for a questionnaire survey, and occupational health examinations were conducted at the affiliated branch of Wuxi Eighth People's Hospital. MWF samples were collected within the factory using the National Institute for Occupational Safety and Health (NIOSH) 5524 method. NAFLD was defined as having a hepatic steatosis index (HSI) ≥ 36 without significant alcohol consumption. The relationship between NAFLD and MWFs was analyzed using logistic regression, and the daily exposure threshold was calculated using R software.

Results

MWF exposure was found to be a risk factor for NAFLD in exposed workers compared to the non-exposed group. The OR for NAFLD in workers exposed to MWFs compared to controls was 1.42 (95% CI: 1.04–1.95). An increased risk of NAFLD was shown to be associated with an increasing dose. The daily exposure dose threshold to MWFs was found to be 6.54 mg/m3 (OR = 2.09, 95% CI: 1.24–3.52).

Conclusion

An association between occupational exposure to MWFs and NAFLD was found. As the concentration of exposure rose, the prevalence of NAFLD was also escalated.

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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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