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在慢性阻塞性肺病实验模型中，AK-7 对 SIRT-2 的药理抑制可通过调节 Nrf2 调节氧化还原状态和细胞凋亡：一项体内和体外研究

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Free Radical Research Pub Date : 2023-12-04 DOI:10.1080/10715762.2023.2288999
Vandana Yadav, Vinita Pandey, Atul Srivastava, Sangita Singh, Subhashini
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引用次数: 0

摘要

慢性阻塞性肺病（COPD）的定义是炎症和肺气肿。Sirtuins（SIRT）是一种依赖于 NAD+ 的组蛋白去乙酰化酶，可调节氧化应激和炎症。SIRT是一种...
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Pharmacological inhibition of SIRT-2 by AK-7 modulates redox status and apoptosis via regulating Nrf2 in an experimental model of chronic obstructive pulmonary disease: an invivo and insilico study
Chronic obstructive pulmonary disease (COPD) is defined by inflammation and emphysema. Sirtuins (SIRT) are NAD+-dependent histone deacetylases that regulate oxidative stress and inflammation. The p...
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来源期刊
Free Radical Research
Free Radical Research 生物-生化与分子生物学
CiteScore
6.70
自引率
0.00%
发文量
47
审稿时长
3 months
期刊介绍： Free Radical Research publishes high-quality research papers, hypotheses and reviews in free radicals and other reactive species in biological, clinical, environmental and other systems; redox signalling; antioxidants, including diet-derived antioxidants and other relevant aspects of human nutrition; and oxidative damage, mechanisms and measurement.
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