F2气连续流动生成2,6-二氯- n -氟吡啶的研究

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Flow Chemistry Pub Date : 2023-11-28 DOI:10.1007/s41981-023-00291-z

Kevin Simon, Desiree Znidar, Gabriel Glotz, Doris Dallinger, C. Oliver Kappe

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引用次数: 0

摘要

以2-6-二氯吡啶和10% F2/N2为原料，连续流动生成N-F试剂2,6-二氯-1-氟四氟硼酸吡啶，并与一种烯胺进行缩尺下游亲电氟化反应的探索性研究。这两步过程在模块化实验室规模的碳化硅流动反应器中进行，该反应器可以安全地处理腐蚀性F2并精确控制温度。结果表明，在−10°C的流动条件下，这两个反应序列都非常快:N-F的生成步骤可以在7.9 s内完成，而烯胺的氟化只需要6.6 s。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Investigations on the continuous flow generation of 2,6-dichloro-N-fluoropyridinium tetrafluoroborate using F2 gas

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Investigations on the continuous flow generation of 2,6-dichloro-N-fluoropyridinium tetrafluoroborate using F2 gas

An explorative study on the continuous flow generation of the N-F reagent 2,6-dichloro-1-fluoro-pyridinium tetrafluoroborate from 2-6-dichloropyridine and 10% F₂/N₂ and its telescoped downstream electrophilic fluorination reaction with an enamine is reported. The 2-step procedure was performed in a modular lab-scale silicon carbide flow reactor, which safely allowed processing corrosive F₂ and precise temperature control. Both reaction sequences turned out to be very fast when carried out in flow at − 10 °C: the N-F generation step could be done within 7.9 s and only 6.6 s were necessary for the fluorination of the enamine.

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来源期刊

Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.