基于间充质干细胞的医学新时代:基础、挑战与展望

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
F.J. Vizoso , L.A. Costa , N. Eiro
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引用次数: 0

摘要

间充质干细胞(MSC)因其再生、抗炎、抗凋亡、抗氧化应激、抗肿瘤或抗菌等特性而引起人们的特别关注。然而,它在临床应用中遇到了细胞治疗的缺点(免疫不相容、肿瘤形成、可能传播感染、进入细胞衰老、安全性、剂量和效力难以评估;储存条件复杂,经济成本高或临床不实用)。考虑到MSC的积极作用在很大程度上是由于其分泌的一组物质(生长因子、细胞因子、趋化因子或微泡)介导的旁分泌作用,这些生物制品的体外获得使药物无细胞再生治疗成为可能,而没有细胞治疗的缺点。然而,这种新的治疗创新意味着挑战,例如对MSC生物异质性的认识以及其分泌组的优化和标准化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nueva era de la medicina basada en las células madre mesenquimales: bases, retos y perspectivas

Stem cells of mesenchymal origin (MSC) arouse special interest due to their regenerative, anti-inflammatory, anti-apoptotic, anti-oxidative stress, antitumor or antimicrobial properties. However, its implementation in the clinic runs into drawbacks of cell therapy (immunological incompatibility, tumor formation, possible transmission of infections, entry into cellular senescence, difficult evaluation of safety, dose and potency; complex storage conditions, high economic cost or impractical clinical use). Considering that the positive effects of MSC are due, to a large extent, to the paracrine effects mediated by the set of substances they secrete (growth factors, cytokines, chemokines or microvesicles), the in vitro obtaining of these biological products makes possible a medicine cell-free regenerative therapy without the drawbacks of cell therapy. However, this new therapeutic innovation implies challenges, such as the recognition of the biological heterogeneity of MSC and the optimization and standardization of their secretome.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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