骨桥蛋白:一种新的呼吸系统疾病治疗靶点。

IF 4.6 2区 医学 Q1 RESPIRATORY SYSTEM
Lung Pub Date : 2024-02-01 Epub Date: 2023-12-07 DOI:10.1007/s00408-023-00665-z
Qi Jia, Yeling Ouyang, Yiyi Yang, Shanglong Yao, Xiangdong Chen, Zhiqiang Hu
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引用次数: 0

摘要

骨桥蛋白(Osteopontin, OPN)是一种参与生理和病理事件的多功能磷酸化蛋白。新出现的证据表明,OPN在呼吸道疾病的发病机制中也起着关键作用。OPN可由肺内各种类型的细胞产生和分泌,在急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)、肺动脉高压(PH)、肺纤维化疾病、肺癌、肺部感染、慢性阻塞性肺疾病(COPD)和哮喘中均发现过表达OPN。OPN在这些呼吸系统疾病的炎症反应、免疫细胞活化、纤维化和组织重塑、肿瘤发生等方面发挥着不同的作用,通过遗传和药理调节OPN在呼吸系统疾病的治疗中发挥着治疗作用。在这篇综述中,我们总结了最近关于OPN在这些呼吸系统疾病中的多方面作用和潜在机制的证据,并且针对OPN似乎是这些疾病的潜在治疗干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Osteopontin: A Novel Therapeutic Target for Respiratory Diseases.

Osteopontin: A Novel Therapeutic Target for Respiratory Diseases.

Osteopontin (OPN) is a multifunctional phosphorylated protein that is involved in physiological and pathological events. Emerging evidence suggests that OPN also plays a critical role in the pathogenesis of respiratory diseases. OPN can be produced and secreted by various cell types in lungs and overexpression of OPN has been found in acute lung injury/acute respiratory distress syndrome (ALI/ARDS), pulmonary hypertension (PH), pulmonary fibrosis diseases, lung cancer, lung infection, chronic obstructive pulmonary disease (COPD), and asthma. OPN exerts diverse effects on the inflammatory response, immune cell activation, fibrosis and tissue remodeling, and tumorigenesis of these respiratory diseases, and genetic and pharmacological moudulation of OPN exerts therapeutic effects in the treatment of respiratory diseases. In this review, we summarize the recent evidence of multifaceted roles and underlying mechanisms of OPN in these respiratory diseases, and targeting OPN appears to be a potential therapeutic intervention for these diseases.

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来源期刊
Lung
Lung 医学-呼吸系统
CiteScore
9.10
自引率
10.00%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.
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