{"title":"阿斯利康/牛津 COVID-19 病例报告：IgA 血管炎。","authors":"Nasser Alzoabi, Jamal Alqahtani, Bader Algamdi, Nada Alghamdi, Ayesha Ahmad, Gaeda Alkaltham, Tala Beidas, Omar Alakloby","doi":"10.23750/abm.v94i6.12959","DOIUrl":null,"url":null,"abstract":"<p><p>Immunoglobulin A (IgA) vasculitis, also known as Henoch-Schönlein purpura, is an immune-mediated vasculitis that affects small vessels. IgA vasculitis could be triggered by numerous conditions including infectious and non-infectious conditions. So far, few reported cases of Covid-19 vaccines related vasculitis. We report a case of IgA vasculitis after AstraZeneca/Oxford COVID-19 vaccine. A 29-year-old healthy man who developed purpuric skin lesions one week after his second AstraZeneca/Oxford COVID-19 vaccine which complicated by glomerulonephritis and gastrointestinal involvement. Skin biopsy revealed fibrinoid necrosis and leukocytoclasia consistent with small vessel vasculitis. Due to the temporal association, AstraZeneca/Oxford COVID-19 vaccine-related IgA vasculitis would be the most likely explanation.</p>","PeriodicalId":93849,"journal":{"name":"Acta bio-medica : Atenei Parmensis","volume":"94 6","pages":"e2023074"},"PeriodicalIF":0.0000,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734242/pdf/","citationCount":"0","resultStr":"{\"title\":\"IgA Vasculitis following AstraZeneca/Oxford COVID-19, case report.\",\"authors\":\"Nasser Alzoabi, Jamal Alqahtani, Bader Algamdi, Nada Alghamdi, Ayesha Ahmad, Gaeda Alkaltham, Tala Beidas, Omar Alakloby\",\"doi\":\"10.23750/abm.v94i6.12959\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Immunoglobulin A (IgA) vasculitis, also known as Henoch-Schönlein purpura, is an immune-mediated vasculitis that affects small vessels. IgA vasculitis could be triggered by numerous conditions including infectious and non-infectious conditions. So far, few reported cases of Covid-19 vaccines related vasculitis. We report a case of IgA vasculitis after AstraZeneca/Oxford COVID-19 vaccine. A 29-year-old healthy man who developed purpuric skin lesions one week after his second AstraZeneca/Oxford COVID-19 vaccine which complicated by glomerulonephritis and gastrointestinal involvement. Skin biopsy revealed fibrinoid necrosis and leukocytoclasia consistent with small vessel vasculitis. Due to the temporal association, AstraZeneca/Oxford COVID-19 vaccine-related IgA vasculitis would be the most likely explanation.</p>\",\"PeriodicalId\":93849,\"journal\":{\"name\":\"Acta bio-medica : Atenei Parmensis\",\"volume\":\"94 6\",\"pages\":\"e2023074\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734242/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta bio-medica : Atenei Parmensis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23750/abm.v94i6.12959\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta bio-medica : Atenei Parmensis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23750/abm.v94i6.12959","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
免疫球蛋白 A（IgA）血管炎又称白癜风，是一种影响小血管的免疫介导的血管炎。引发 IgA 血管炎的原因有很多，包括感染性和非感染性疾病。迄今为止，与 Covid-19 疫苗相关的血管炎病例报道很少。我们报告了一例阿斯利康/牛津 COVID-19 疫苗后的 IgA 血管炎病例。一名 29 岁的健康男性在第二次接种阿斯利康/牛津 COVID-19 疫苗一周后出现紫癜性皮肤损害，并并发肾小球肾炎和胃肠道受累。皮肤活检发现纤维素性坏死和白细胞减少与小血管炎一致。由于时间上的关联，阿斯利康/牛津 COVID-19 疫苗相关的 IgA 血管炎是最有可能的解释。
IgA Vasculitis following AstraZeneca/Oxford COVID-19, case report.
Immunoglobulin A (IgA) vasculitis, also known as Henoch-Schönlein purpura, is an immune-mediated vasculitis that affects small vessels. IgA vasculitis could be triggered by numerous conditions including infectious and non-infectious conditions. So far, few reported cases of Covid-19 vaccines related vasculitis. We report a case of IgA vasculitis after AstraZeneca/Oxford COVID-19 vaccine. A 29-year-old healthy man who developed purpuric skin lesions one week after his second AstraZeneca/Oxford COVID-19 vaccine which complicated by glomerulonephritis and gastrointestinal involvement. Skin biopsy revealed fibrinoid necrosis and leukocytoclasia consistent with small vessel vasculitis. Due to the temporal association, AstraZeneca/Oxford COVID-19 vaccine-related IgA vasculitis would be the most likely explanation.
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