睾丸性索间质肿瘤的当代最新进展。

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-03-01 Epub Date: 2023-12-06 DOI:10.1097/PAP.0000000000000423

Andrés M Acosta, Muhammad T Idrees, Daniel M Berney, Maurizio Colecchia

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引用次数: 0

摘要

睾丸性索间质瘤（TSCST）相对罕见，约占睾丸肿瘤总数的 5%。从历史上看，睾丸性索间质瘤被分为三大类：莱德细胞瘤、绒毛膜细胞瘤和颗粒细胞瘤。近年来，免疫表型和分子分析使人们对这些肿瘤的生物学和基因组特征有了更详细的了解，从而描述了一些新的实体，其中一些已被纳入最新的世界卫生组织分类。本综述总结了组织病理学、临床和分子方面的新发现，这些发现可能会促使人们重新评估已确立的概念，并有助于在未来几年改进 TSCST 的诊断和临床管理。

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Contemporary Updates on Sex Cord-stromal Tumors of the Testis.

Testicular sex cord-stromal tumors (TSCSTs) are relatively rare, representing ~5% of testicular neoplasms overall. Historically, TSCSTs have been classified into 3 major entities: Leydig cell tumor, Sertoli cell tumor, and granulosa cell tumor. In recent years, immunophenotypic and molecular analyses have led to a more detailed understanding of the biological and genomic features of these neoplasms, resulting in the description of new entities, some of which have been included in the latest WHO classification. This review summarizes novel histopathologic, clinical, and molecular findings that may lead to a reappraisal of established concepts and help improve the diagnosis and clinical management of TSCSTs in the coming years.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.