血培养时间与阳性、死亡率和菌血症严重程度的关系。

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES

Infectious diseases now Pub Date : 2023-12-01 DOI:10.1016/j.idnow.2023.104843

N. Deguchi , K. Ishikawa , S. Tokioka , D. Kobayashi , N. Mori

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引用次数: 0

摘要

目的:我们调查由各种病原体引起的菌血症患者严重程度或死亡率与阳性时间之间的关系。患者和方法:这项单中心回顾性研究纳入了血培养结果阳性的患者。结果:较长的阳性时间与金黄色葡萄球菌的30天死亡率相关(221例，30天死亡率组为17.4 h，生存组为14.1 h)。年龄、慢性肾脏疾病、脑血管疾病、高血压药物使用、意识障碍和最低收缩压是30天死亡率的重要预测因素。金黄色葡萄球菌在阳性时间> 24 h时，30天内死亡率显著增高(p = 0.04)。肺炎链球菌、α、β溶血性链球菌、肠球菌、肠杆菌科、葡萄糖非发酵革兰氏阴性杆状菌、念珠菌和厌氧菌的阳性时间与30天死亡率无显著相关性。结论:在各种病原菌中，到达阳性时间> 24 h与金黄色葡萄球菌的30天死亡率相关。

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Relationship between blood culture time to positivity, mortality rate, and severity of bacteremia

Objectives

We investigated the association between patient severity or mortality and time to positivity in bacteremia caused by various pathogens.

Patients and methods

This single-center retrospective study included patients with positive blood culture results.

Results

Longer time to positivity was associated with 30-day mortality for Staphylococcus aureus (221 cases, time to positivity: 17.4 h in the 30-day mortality group vs. 14.1 h in the survival group). Age, chronic kidney disease, cerebrovascular disease, hypertensive drug use, consciousness disorder, and minimal systolic blood pressure were significant predictors of 30-day mortality. For S. aureus, mortality within 30 days was significantly higher when time to positivity was > 24 h (p = 0.04). The time to positivity of Streptococcus pneumoniae, α, β-hemolytic Streptococcus, Enterococcus sp., Enterobacteriaceae, glucose-nonfermenting Gram-negative rods, Candida sp., and anaerobe was not significantly associated with 30-day mortality.