虚拟外部刺激促进大脑状态从早期轻度认知障碍到健康的转变

Brain-X Pub Date : 2023-11-29 DOI:10.1002/brx2.41
Weiping Wang, Weiwei Wang, Haiyan Zhao, Zhen Wang, Xiong Luo, Jipeng Ouyang
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引用次数: 0

摘要

神经刺激已成为早期轻度认知障碍(EMCI)的潜在治疗方法。然而,脑区外部刺激如何促进脑状态从EMCI到健康的转变以及靶位的选择,还需要进一步探索。本研究利用功能磁共振成像数据集评估健康个体和EMCI患者的大脑状态,探索EMCI的概率亚稳态亚状态空间,识别EMCI的异常表现。然后确定增产目标并进行增产,以实现EMCI有效连接网络的完全可控。基于弥散张量成像数据的全脑模型成功拟合了EMCI患者的脑状态。基于该全脑模型,刺激海马、额叶内侧回、枕下回和梭状回可以促进大脑状态从EMCI向健康状态的转变。研究结果揭示了EMCI患者认知能力下降的潜在脑机制以及EMCI恢复的神经机制的刺激靶点,有助于设计更有效的EMCI治疗干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Virtual external stimulation promotes the transformation of the brain state from early mild cognitive impairment to health

Virtual external stimulation promotes the transformation of the brain state from early mild cognitive impairment to health

Neurostimulation has emerged as a potential remedy for early mild cognitive impairment (EMCI). However, further exploration is needed on how external stimulation of brain regions promotes the transition of the brain state from EMCI to health and the selection of target locations. In this study, a functional magnetic resonance imaging dataset was used to evaluate the brain states of healthy individuals and patients with EMCI to explore the probabilistic metastable substate space, identifying abnormal manifestations of EMCI. Stimulation targets were then identified and stimulated to achieve complete controllability of the effective connection network for EMCI. A whole-brain model successfully fitted the brain state of the patients with EMCI based on diffusion tensor imaging data. Based on this whole-brain model, stimulation of the hippocampus, medial frontal gyrus, suboccipital gyrus, and fusiform gyrus can promote the transformation of the brain state from EMCI to health. The findings reveal the underlying brain mechanisms of cognitive decline in patients with EMCI and the stimulation targets of the neural mechanisms of EMCI restoration, which could help in designing more effective therapeutic interventions for EMCI.

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