蜜蜂的表观遗传学机制:蜂王浆的秘密。

IF 3.2 Q2 GENETICS & HEREDITY
Epigenetics Insights Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI:10.1177/25168657231213717
Mahmoud Alhosin
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引用次数: 0

摘要

蜜蜂的早期饮食对表观基因组有影响,对其表型有影响。根据幼虫早期的饮食,要么是蜂王浆(RJ),要么是工蜂,两个不同的雌性种姓从相同的基因组中产生,一个长寿的、卵巢发育完全的蜂王和一个寿命短、功能不育的工蜂。为了在蜂王和工蜂之间产生这些突出的生理和形态差异,蜜蜂利用由营养输入控制的表观遗传机制。这些机制包括DNA甲基化和组蛋白翻译后修饰,主要是组蛋白乙酰化。在蜜蜂幼虫中,RJ可能会改变DNA甲基化和组蛋白乙酰化。该饲料含有生物活性成分,对新生甲基转移酶DNMT3A或组蛋白去乙酰化酶3 HDAC3具有抑制作用,以形成和维持幼虫发育产生蜂后所需的表观遗传状态。DNMT和HDAC酶共同作用,诱导形成致密的染色质结构,抑制转录。这种对话可能通过它们与其他表观遗传因子的关联来协调,包括泛素样含植物同源结构域(PHD)和真正有趣的新基因(RING)手指结构域1 (UHRF1)。通过其多个功能域,UHRF1作为DNA甲基化模式和组蛋白标记的表观遗传读取器。本文讨论了蜜蜂染色质的表观遗传调控,以及蜜蜂早期饮食如何影响刺激幼虫变成蜂王或工蜂所必需的DNA/组蛋白修饰机制类型。综述还展望了未来蜜蜂表观遗传学机制的研究方向,主要是UHRF1在这些机制中的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epigenetics Mechanisms of Honeybees: Secrets of Royal Jelly.

Early diets in honeybees have effects on epigenome with consequences on their phenotype. Depending on the early larval diet, either royal jelly (RJ) or royal worker, 2 different female castes are generated from identical genomes, a long-lived queen with fully developed ovaries and a short-lived functionally sterile worker. To generate these prominent physiological and morphological differences between queen and worker, honeybees utilize epigenetic mechanisms which are controlled by nutritional input. These mechanisms include DNA methylation and histone post-translational modifications, mainly histone acetylation. In honeybee larvae, DNA methylation and histone acetylation may be differentially altered by RJ. This diet has biologically active ingredients with inhibitory effects on the de novo methyltransferase DNMT3A or the histone deacetylase 3 HDAC3 to create and maintain the epigenetic state necessary for developing larvae to generate a queen. DNMT and HDAC enzymes work together to induce the formation of a compacted chromatin structure, repressing transcription. Such dialog could be coordinated by their association with other epigenetic factors including the ubiquitin-like containing plant homeodomain (PHD) and really interesting new gene (RING) finger domains 1 (UHRF1). Through its multiple functional domains, UHRF1 acts as an epigenetic reader of both DNA methylation patterns and histone marks. The present review discusses the epigenetic regulation of honeybee's chromatin and how the early diets in honeybees can affect the DNA/histone modifying types of machinery that are necessary to stimulate the larvae to turn into either queen or worker. The review also looks at future directions in epigenetics mechanisms of honeybees, mainly the potential role of UHRF1 in these mechanisms.

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来源期刊
Epigenetics Insights
Epigenetics Insights GENETICS & HEREDITY-
CiteScore
5.10
自引率
0.00%
发文量
10
审稿时长
8 weeks
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