阿尔茨海默病和癌症:共同目标。

IF 3.3 3区医学 Q2 CHEMISTRY, MEDICINAL

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0113895575263108231031132404

Xueqing Yang, Jinlian Dai, Chenglong Wu, Zongliang Liu

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引用次数: 0

摘要

越来越多的流行病学证据表明，癌症与AD呈负相关。此外，细胞的生存和死亡都受相同的信号通路调控，其异常调控可能与癌症和AD的发生发展有关。研究表明，在癌症和AD之间可能存在共同的分子机制。本文将讨论GSK3、DAPK1、PP2A、P53和CB2R在癌症和AD发病机制中的作用，并描述基于这些靶点的药物开发的研究现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Alzheimer's Disease and Cancer: Common Targets.

There is growing epidemiologic evidence of an inverse association between cancer and AD. In addition, both cell survival and death are regulated by the same signaling pathways, and their abnormal regulation may be implicated in the occurrence and development of cancer and AD. Research shows that there may be a common molecular mechanism between cancer and AD. This review will discuss the role of GSK3, DAPK1, PP2A, P53 and CB2R in the pathogenesis of cancer and AD and describe the current research status of drug development based on these targets.

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来源期刊

Mini reviews in medicinal chemistry 医学-医药化学

CiteScore

7.80

自引率

0.00%

发文量

231

审稿时长

6 months

期刊介绍： The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.