白介素-6基因变异(rs1800795、rs1800796、rs1554606、rs1800797、rs2069840、rs12700386和rs2069861)作为乳腺癌预后标志物的分析:系统综述、meta分析和网络分析

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Interferon and Cytokine Research Pub Date : 2024-01-01 Epub Date: 2023-11-29 DOI:10.1089/jir.2023.0090
Ali Azizi, Nasrin Mansouri, Mitra Tarlan, Masoud Sadeghi
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引用次数: 0

摘要

白细胞介素-6 (IL-6)具有明显的促瘤和抑瘤作用,可诱导人乳腺癌细胞上皮-间质转化表型,并可能促进乳腺癌转移。在此,我们旨在评估IL-6变异(rs1800795、rs1800796、rs1554606、rs1800797、rs2069840、rs12700386和rs2069861)与BC易感性的关系。检索PubMed/Medline、Web of Science、Scopus、Cochrane Library等数据库至2022年12月19日,无任何限制。每个研究的质量评估是基于纽卡斯尔-渥太华量表工具进行的。Review Manager 5.3软件显示了包括优势比(OR)和95%置信区间(CI)在内的效应大小。发表偏倚和敏感性分析均采用综合meta分析2.0版软件进行。在数据库中共识别2508条记录,最终有27篇文章被纳入meta分析。IL-6的7个多态性被纳入分析。优势模型只有rs1800797多态性(OR = 1.51;95% ci = 1.15-2.00;P = 0.003),杂合子rs2069840多态性(OR = 0.89;95% ci = 0.81-0.97;P = 0.008)和显性(OR = 0.91;95% ci = 0.84-0.99;P = 0.02)模型与BC风险显著相关。综上所述,在7个多态性中,除了少数纳入病例外,本meta分析提示rs1800797多态性的AA+GA基因型在BC患者中具有显著升高的风险,rs2069840多态性的GC和CC+GC基因型在BC患者中具有保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of Interleukin-6 Gene Variants (rs1800795, rs1800796, rs1554606, rs1800797, rs2069840, rs12700386, and rs2069861) as Prognostic Markers in Breast Cancer: A Systematic Review, Meta-Analysis, and Network Analysis.

Interleukin-6 (IL-6) has obviously tumor-promoting and tumor-inhibitory effects and can induce an epithelial-mesenchymal transition phenotype in human breast cancer (BC) cells and implicate its potential to promote BC metastasis. Herein, we aimed to evaluate the association of IL-6 variants (rs1800795, rs1800796, rs1554606, rs1800797, rs2069840, rs12700386, and rs2069861) with the susceptibility to BC. The databases of PubMed/Medline, Web of Science, Scopus, and Cochrane Library were searched until December 19, 2022, without any restrictions. The quality assessment of each study was performed based on the Newcastle-Ottawa Scale tool. The Review Manager 5.3 software presented the effect sizes including odds ratio (OR) along with a 95% confidence interval (CI). Both publication bias and sensitivity analyses were carried out by the Comprehensive Meta-Analysis version 2.0 software. A total of 2,508 records were identified among databases and at last, 27 articles were entered into the meta-analysis. Seven polymorphisms of IL-6 were entered into the analyses. Just rs1800797 polymorphism in the dominant model (OR = 1.51; 95% CI = 1.15-2.00; P = 0.003) and rs2069840 polymorphism in heterozygous (OR = 0.89; 95% CI = 0.81-0.97; P = 0.008) and dominant (OR = 0.91; 95% CI = 0.84-0.99; P = 0.02) models had a significant association with the BC risk. In conclusion, among 7 polymorphisms and despite a few included cases, the present meta-analysis recommended that the AA+GA genotype of rs1800797 polymorphism had a significantly elevated risk and the GC and the CC+GC genotypes of rs2069840 polymorphism had a protective role in the BC patients.

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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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