[健身用合成代谢类固醇继发的塌陷肾小球病:一个病例系列]。

Q4 Medicine
Roberta Passaro, Pierluigi D'Angiò, Simona Laurino, Giuseppe Gigliotti, Antonio Massa, Antonio Mancini, Annalisa Gonnella, Anna Giammarino, Gianmarco Borriello
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引用次数: 0

摘要

滥用合成代谢雄激素(AAS)用于竞技(和非竞技)目的的健身练习越来越普遍。这些物质对各种器官的影响目前还不完全清楚。使用AAS后发生FSGS的病例在文献中也有报道,甚至演变为ESKD。我们描述了3例长期服用AAS后出现肾功能指标改变的健美运动员。3例肾活检,病理诊断为FSGS塌陷变异。我们检查在组织学检查中观察到的病变。两名运动员肾脏疾病进展迅速,需要替代治疗。第三例继续保守治疗慢性肾衰竭。我们讨论了与摄入兴奋剂物质有关的风险,以及健美运动员如何暴露于不同原因的肾脏损害:合成代谢类固醇、补充剂和高蛋白饮食。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Collapsing Glomerulopathy Secondary to Anabolic Steroids for Bodybuilding: A Case Series].

The abuse of anabolic androgenic steroids (AAS) for competitive (and non-competitive) purposes for bodybuilding practice is increasingly common. The consequences of these substances on the various organs are only partially known. Cases of FSGS following the use of AAS have been reported in the literature, even with evolution to ESKD. We describe three cases of bodybuilding athletes who presented alterations in renal function indices after taking AAS for a long time. Three renal biopsies were performed with histological diagnosis of FSGS collapsing variant. We examine the lesions observed on histological examination. Two athletes had rapid progression of renal disease requiring replacement therapy. The third one continues conservative treatment for chronic renal failure. We discuss the risks related to the intake of doping substances and how bodybuilders are exposed to different causes of kidney damage: anabolic steroids, supplements, and a high-protein diet.

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来源期刊
CiteScore
0.70
自引率
0.00%
发文量
62
期刊介绍: Il Giornale Italiano di Nefrologia (GIN) è la rivista di educazione continua della Società Italiana di Nefrologia SIN ed è pubblicato bimestralmente. E" il più autorevole organo di informazione nefrologia disponibile a livello nazionale. Il giornale Italiano di Nefrologia offre la più aggiornata informazione medico-scientifica rivolta al nefrologo sotto forma di rassegne, casi clinici e articoli finalizzati all’Educazione Continua in Medicina, oltre ai notiziari ed agli atti dei congressi di questa prestigiosa Società Scientifica
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