胰岛素生长因子-1在化脓性汗腺炎中的地位:一项法国机构试点研究。

Perrine Rousseau, Alexandra Poinas, Damien Masson, Kalyane Bach-Ngohou, Michel Nguyen, Marie Le Moigne, Barbara Bregeon, Florence Vrignaud, Amir Khammari, Brigitte Dréno
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引用次数: 0

摘要

背景:化脓性汗腺炎(HS)是大汗腺中卵泡的慢性炎症性皮肤病,与皮肤先天免疫缺陷有关。它的特点是出现结节、脓肿、瘘管、疤痕。目的:虽然HS与先天免疫之间的关系已经被证实,但HS患者的IGF-1状态仍然未知。本初步研究的目的是确定HS患者的IGF-1状态及其与该疾病临床特征的潜在关系。方法:本研究为单中心横断面研究,纳入2014年11月至2018年1月在南特医学院皮肤科住院的39例患者。随访时收集临床资料和IGF1状态。结果:49%的患者IGF-1水平很低。在临床水平上,这些患者年轻,病程短。主要的区别是igf1缺陷患者的BMI高于其他人。两组患者其他因素差异无统计学意义。结论:本探索性前期研究提示,低水平IGF-1可能代表HS患者的一种特定表型。这些初步结果必须在更大的队列中得到证实,因为它们可能对这些患者的治疗护理产生实际影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Insulin Growth Factor-1 Status in Hidradenitis Suppurativa: A French Institutional Pilot Study.

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of the follicles in the apocrine glands and is associated with a deficiency in the innate immunity of the skin. It is characterized by the occurrence of nodules, abscesses, fistulas, scars.

Objective: Although a relationship has already been demonstrated between HS and innate immunity, IGF-1 status in patients with HS is still unknown. The objective of this pilot study was to determine IGF-1 status in patients with HS as well as its potential relationship with the clinical profile of the disease.

Methods: This monocentric and cross-sectional study involved 39 patients hospitalized at the Dermatology Department of CHU Nantes between November 2014 and January 2018. Clinical data and IGF1 status were collected during the follow-up consultation.

Results: Forty-nine percent of the patients had very low levels of IGF-1. At the clinical level, these patients were young and with a short duration of disease. The major difference was that IGF1-deficient patients had a higher BMI than others. The others factors differing between the two patient groups did not reach statistical significance.

Conclusion: This exploratory pilot study indicates that HS with a low level of IGF-1 could represent a specific phenotype of patients with HS. These preliminary results have to be confirmed with a larger cohort, as they could have practical consequences in the therapeutic care of these patients.

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