产前纤维蛋白原水平是胎盘早剥严重程度的预测指标

IF 1.5 Q3 OBSTETRICS & GYNECOLOGY
Nadiye Köroğlu , Ahmet Tayyar , Ali Soydar , Nazli Albayrak , Turgut Aydın , Berna Aslan Çetin
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引用次数: 0

摘要

目的探讨产前纤维蛋白原水平对胎盘早剥患者不良结局的预测作用。材料和方法我们对2012年1月至2018年5月期间因胎盘早剥入院的所有女性进行了回顾性研究。评估产后出血(PPH)、弥散性血管内凝血(DIC)、大量输血和重症监护病房住院参数对产妇结局的影响。新生儿结局评估5分钟APGAR评分、脐动脉pH值和死胎。结果产前平均纤维蛋白原水平为221.3±111.6 mg/dL。在多变量logistic回归分析中,纤维蛋白原水平被确定为PPH、红细胞浓缩物(RCC)和新鲜冷冻血浆(FFP)输注的独立指标。当纤维蛋白原水平低于130 mg/dL时,PPH的风险增加,当纤维蛋白原水平低于100 mg/dL时,显性DİC的风险增加,红细胞浓缩物和新鲜冷冻血浆输血的风险也增加。就胎儿结果而言,当纤维蛋白原水平低于250 mg/dL时,可能会出现不良的新生儿结局。结论产前纤维蛋白原水平是预测胎盘早剥产妇不良结局的良好指标。此外,纤维蛋白原水平可能是处理胎盘早剥病例的指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pre-delivery fibrinogen level is a predictor for severity of placental abruption

Objective

To determine pre-delivery fibrinogen levels in predicting adverse maternal or neonatal outcomes in patients with placental abruption.

Materials and method

We conducted a retrospective study of all women admitted for placental abruption between January 2012 and May 2018. Postpartum hemorrhage (PPH), disseminated intravascular coagulation (DIC), massive blood transfusion and hospitalization in intensive care unit parameters were evaluated for maternal outcomes. For the neonatal outcomes, the 5th minute APGAR score, umbilical artery pH and stillbirth were evaluated.

Results

The mean predelivery fibrinogen levels were 221.3 ± 111.6 mg/dL. In multivariate logistic regression analysis, fibrinogen level was determined as an independent indicator for PPH, red cell concentrate (RCC) and fresh frozen plasma (FFP) transfusion. When fibrinogen levels decreased below 130 mg/dL, the risk of PPH increased and when fibrinogen levels decreased below 100 mg/dL, the risk of overt DİC and also the risk of red cell concentrate and fresh frozen plasma transfusion increased. In terms of the fetal results, there may be adverse neonatal outcomes when fibrinogen levels are below 250 mg/dL.

Conclusion

Predelivery fibrinogen levels are good indicators for predicting adverse maternal outcomes in placental abruption cases. In addition, fibrinogen levels might be a guide for management of placental abruption cases.

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来源期刊
CiteScore
2.20
自引率
0.00%
发文量
31
审稿时长
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