{"title":"细胞遗传学异常对症状性多发性骨髓瘤的影响关西骨髓瘤论坛对日本现实世界的分析","authors":"Aya Nakaya , Hirohiko Shibayama , Nobuhiko Uoshima , Ryosuke Yamamura , Satoshi Yoshioka , Kazunori Imada , Yuji Shimura , Masaaki Hotta , Toshimitsu Matsui , Satoru Kosugi , Hitoshi Hanamoto , Hitoji Uchiyama , Satoshi Yoshihara , Shin-ichi Fuchida , Yoshiyuki Onda , Yasuhiro Tanaka , Kensuke Ohta , Mitsuhiro Matsuda , Junya Kanda , Adachi Yoko , Masayuki Hino","doi":"10.1016/j.lrr.2023.100395","DOIUrl":null,"url":null,"abstract":"<div><p>To evaluate the specific prognostic value of CAs, we conducted an analysis of 923 symptomatic multiple myeloma patients. Among this cohort, 480 patients had complete data set of high-risk CAs by interphase fluorescent in situ hybridization at diagnosis. In the high-risk group analysis, the median OS of patients without CAs (<em>n</em> = 338, 72 %) was 6.5 years, patients with del(17p) (<em>n</em> = 42, 9 %) was 4.4 years, patients with t(4;14) or t(14;16) (<em>n</em> = 72, 15 %) was 4.4 years, and patients with double-positive CAs(del(17p) and t(4;14) or t(14;16)) (<em>n</em> = 18, 4 %) was 2.1 years (<em>p</em> = 0.032). Patients with double-positive CAs had a significantly worse prognosis.</p></div>","PeriodicalId":38435,"journal":{"name":"Leukemia Research Reports","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213048923000353/pdfft?md5=da41e0ae4551170b1083dfbc3d685562&pid=1-s2.0-S2213048923000353-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Impact of cytogenetic abnormalities in symptomatic multiple myeloma; a Japanese real-world analysis from Kansai Myeloma Forum\",\"authors\":\"Aya Nakaya , Hirohiko Shibayama , Nobuhiko Uoshima , Ryosuke Yamamura , Satoshi Yoshioka , Kazunori Imada , Yuji Shimura , Masaaki Hotta , Toshimitsu Matsui , Satoru Kosugi , Hitoshi Hanamoto , Hitoji Uchiyama , Satoshi Yoshihara , Shin-ichi Fuchida , Yoshiyuki Onda , Yasuhiro Tanaka , Kensuke Ohta , Mitsuhiro Matsuda , Junya Kanda , Adachi Yoko , Masayuki Hino\",\"doi\":\"10.1016/j.lrr.2023.100395\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>To evaluate the specific prognostic value of CAs, we conducted an analysis of 923 symptomatic multiple myeloma patients. Among this cohort, 480 patients had complete data set of high-risk CAs by interphase fluorescent in situ hybridization at diagnosis. In the high-risk group analysis, the median OS of patients without CAs (<em>n</em> = 338, 72 %) was 6.5 years, patients with del(17p) (<em>n</em> = 42, 9 %) was 4.4 years, patients with t(4;14) or t(14;16) (<em>n</em> = 72, 15 %) was 4.4 years, and patients with double-positive CAs(del(17p) and t(4;14) or t(14;16)) (<em>n</em> = 18, 4 %) was 2.1 years (<em>p</em> = 0.032). Patients with double-positive CAs had a significantly worse prognosis.</p></div>\",\"PeriodicalId\":38435,\"journal\":{\"name\":\"Leukemia Research Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2213048923000353/pdfft?md5=da41e0ae4551170b1083dfbc3d685562&pid=1-s2.0-S2213048923000353-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Leukemia Research Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213048923000353\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Leukemia Research Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213048923000353","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Impact of cytogenetic abnormalities in symptomatic multiple myeloma; a Japanese real-world analysis from Kansai Myeloma Forum
To evaluate the specific prognostic value of CAs, we conducted an analysis of 923 symptomatic multiple myeloma patients. Among this cohort, 480 patients had complete data set of high-risk CAs by interphase fluorescent in situ hybridization at diagnosis. In the high-risk group analysis, the median OS of patients without CAs (n = 338, 72 %) was 6.5 years, patients with del(17p) (n = 42, 9 %) was 4.4 years, patients with t(4;14) or t(14;16) (n = 72, 15 %) was 4.4 years, and patients with double-positive CAs(del(17p) and t(4;14) or t(14;16)) (n = 18, 4 %) was 2.1 years (p = 0.032). Patients with double-positive CAs had a significantly worse prognosis.
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