牙根发生的时空细胞动力学与分子调控。

IF 10.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Pengcheng Rao, Junjun Jing, Yi Fan, Chenchen Zhou
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引用次数: 0

摘要

牙根发育涉及复杂的时空细胞动力学和分子调控。Hertwig’s上皮根鞘(Hertwig’s epithelial root sheath, HERS)的形成诱导成牙细胞分化和随后的根状牙本质沉积。精确控制的信号通路调节HERS的行为和牙间充质干细胞(DMSCs)的命运。这些通路的中断会导致根发育缺陷,如根变短和功能异常。牙干细胞、生物材料和生物打印技术的进步为生物工程牙根再生提供了巨大的希望。然而,在临床治疗中,复制牙形成的复杂发育尚未得到解决,这仍然是该领域的主要挑战。目前正在进行的关于牙根发育机制、先进生物材料和制造技术的研究将使下一代生物牙根再生成为可能,从而恢复牙根的生理结构和功能。本文综述了近年来在牙根发生机制方面的最新发现,并讨论了最近在发展新的基于生物学的牙科治疗方面的一些重要发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny.

Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny.

Tooth root development involves intricate spatiotemporal cellular dynamics and molecular regulation. The initiation of Hertwig's epithelial root sheath (HERS) induces odontoblast differentiation and the subsequent radicular dentin deposition. Precisely controlled signaling pathways modulate the behaviors of HERS and the fates of dental mesenchymal stem cells (DMSCs). Disruptions in these pathways lead to defects in root development, such as shortened roots and furcation abnormalities. Advances in dental stem cells, biomaterials, and bioprinting show immense promise for bioengineered tooth root regeneration. However, replicating the developmental intricacies of odontogenesis has not been resolved in clinical treatment and remains a major challenge in this field. Ongoing research focusing on the mechanisms of root development, advanced biomaterials, and manufacturing techniques will enable next-generation biological root regeneration that restores the physiological structure and function of the tooth root. This review summarizes recent discoveries in the underlying mechanisms governing root ontogeny and discusses some recent key findings in developing of new biologically based dental therapies.

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来源期刊
International Journal of Oral Science
International Journal of Oral Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
31.80
自引率
1.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: The International Journal of Oral Science covers various aspects of oral science and interdisciplinary fields, encompassing basic, applied, and clinical research. Topics include, but are not limited to: Oral microbiology Oral and maxillofacial oncology Cariology Oral inflammation and infection Dental stem cells and regenerative medicine Craniofacial surgery Dental material Oral biomechanics Oral, dental, and maxillofacial genetic and developmental diseases Craniofacial bone research Craniofacial-related biomaterials Temporomandibular joint disorder and osteoarthritis The journal publishes peer-reviewed Articles presenting new research results and Review Articles offering concise summaries of specific areas in oral science.
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