左侧纹状体-苍白叶投影过度活跃。第一部分:低层次理论。

Psychiatric developments Pub Date : 1989-01-01
T S Early, M I Posner, E M Reiman, M E Raichle
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引用次数: 0

摘要

我们观察到左侧白球的相对血流量增加,并有证据表明,在抗精神病药未发作的精神分裂症患者中存在轻微的右半半球忽视。这些发现出现在某些损伤(如中脑多巴胺能神经元的单侧破坏)后的动物中,并且被认为是由于左纹状体-苍白质过度活跃。一项文献调查揭示了单侧多巴胺能失神经的动物和精神分裂症患者之间的许多相似之处。此前有人提出,现有证据并不能排除精神分裂症患者存在多巴胺能缺乏症的可能性。其他研究表明,抗精神病药逆转了多巴胺转换指数的不对称性。一个基于多巴胺能半缺失的模型被概述出来,并且可以潜在地解释精神分裂症患者的其他异常,包括眼动异常和颞叶癫痫与精神病之间的联系。一篇配套文章描述了这个模型如何解释精神病的一些现象学症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hyperactivity of the left striato-pallidal projection. Part I: Lower level theory.

We have observed increased relative blood flow to the left globus pallidus and evidence for subtle forms of right-sided hemineglect in neuroleptic-naive schizophrenic patients. These findings occur in animals following certain lesions such as unilateral destruction of midbrain dopaminergic neurons, and are presumed to be due to left striato-pallidal hyperactivity. A survey of the literature reveals many similarities between animals with unilateral dopaminergic denervation and schizophrenic patients. It has previously been suggested that available evidence does not preclude the possibility that schizophrenic patients have something like a dopaminergic deficiency. Other studies demonstrate that neuroleptics reverse asymmetries in indices of dopamine turnover. A model based upon dopaminergic hemideficiency is outlined, and can potentially explain other abnormalities in schizophrenic patients including eye movement abnormalities and the link between temporal lobe epilepsy and psychosis. A companion article describes how this model can account for some of the phenomenological symptoms of psychosis.

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