Sema Çarıkçı, Turgut Kılıç, Ahmet C Gören, Tuncay Dirmenci, Gülbahar Özge Alim Toraman, Gülaçtı Topçu
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(Lamiaceae) is represented by 46 species in Turkey with an 79% endemism ratio, 42 of 46 belonging to the section Empodoclia.</p><p><strong>Objective: </strong>In this review article, <i>Sideritis</i> species growing in Turkey have been evaluated for phytochemical constituents and biological activities.</p><p><strong>Methods: </strong>The data for the isolates, components and extracts of the Anatolian <i>Sideritis</i> species and their bioactivity studies were retrieved from the main databases WoS, Scopus and PubMed from 1975 until 31 December 2022.</p><p><strong>Results: </strong>In this review article, terpenoids, flavonoids, phenolics and other secondary metabolites isolated from Turkish <i>Sideritis</i> species were reported. Anatolian <i>Sideritis</i> species, which primarily consist of monoterpenes and sesquiterpenes, were studied in detail. <i>Sideritis</i> plants are represented by 46 species in Turkey, and 25 of them were investigated for their diterpenoids through isolation or LC-MS studies. Most of the diterpenoids of Turkish <i>Sideritis</i> species have <i>ent</i>-kaurene skeleton, among them linearol, siderol, 7-<i>epi</i>candicandiol and sideridiol were found to be the main compounds. Exceptionally, labdane, pimarane and beyerene diterpenoids were only found in a few species. For phenolics and flavonoids, only 12 species were investigated until now, and they were found to be rich in phenylethanoid glycosides and flavonoid glycosides. In terms of activity, most of the species were tested for antioxidant activity, followed by antimicrobial and anti-ulcer/anti-inflammatory activities. Their cytotoxic, enzyme inhibitory, antinociceptive and antistress activities were less frequently studied.</p><p><strong>Conclusions: </strong><i>Sideritis</i> species should be considered promising therapeutic agents in the treatment of upper respiratory tract and ulcer/inflammatory diseases.</p>","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"61 1","pages":"1484-1511"},"PeriodicalIF":3.9000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001281/pdf/","citationCount":"0","resultStr":"{\"title\":\"Chemical profile of the Anatolian <i>Sideritis</i> species with bioactivity studies.\",\"authors\":\"Sema Çarıkçı, Turgut Kılıç, Ahmet C Gören, Tuncay Dirmenci, Gülbahar Özge Alim Toraman, Gülaçtı Topçu\",\"doi\":\"10.1080/13880209.2023.2280253\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>The genus <i>Sideritis</i> L. (Lamiaceae) is represented by 46 species in Turkey with an 79% endemism ratio, 42 of 46 belonging to the section Empodoclia.</p><p><strong>Objective: </strong>In this review article, <i>Sideritis</i> species growing in Turkey have been evaluated for phytochemical constituents and biological activities.</p><p><strong>Methods: </strong>The data for the isolates, components and extracts of the Anatolian <i>Sideritis</i> species and their bioactivity studies were retrieved from the main databases WoS, Scopus and PubMed from 1975 until 31 December 2022.</p><p><strong>Results: </strong>In this review article, terpenoids, flavonoids, phenolics and other secondary metabolites isolated from Turkish <i>Sideritis</i> species were reported. Anatolian <i>Sideritis</i> species, which primarily consist of monoterpenes and sesquiterpenes, were studied in detail. <i>Sideritis</i> plants are represented by 46 species in Turkey, and 25 of them were investigated for their diterpenoids through isolation or LC-MS studies. Most of the diterpenoids of Turkish <i>Sideritis</i> species have <i>ent</i>-kaurene skeleton, among them linearol, siderol, 7-<i>epi</i>candicandiol and sideridiol were found to be the main compounds. Exceptionally, labdane, pimarane and beyerene diterpenoids were only found in a few species. For phenolics and flavonoids, only 12 species were investigated until now, and they were found to be rich in phenylethanoid glycosides and flavonoid glycosides. In terms of activity, most of the species were tested for antioxidant activity, followed by antimicrobial and anti-ulcer/anti-inflammatory activities. 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引用次数: 0
摘要
背景:在土耳其有46种Sideritis L. (Lamiaceae),特有率79%,其中42种属于Empodoclia剖面。目的:对生长在土耳其的黄芪属植物的化学成分和生物活性进行了评价。方法:检索1975年至2022年12月31日世界主要数据库WoS、Scopus和PubMed中Anatolian Sideritis的分离物、成分和提取物及其生物活性研究数据。结果:本文报道了从土耳其黄芪属植物中分离得到的萜类、黄酮类、酚类等次生代谢产物。对主要由单萜类和倍半萜类组成的安纳托利亚黄芪属植物进行了详细的研究。土耳其有46种黄芪属植物,通过分离或LC-MS研究了其中25种植物的二萜类化合物。土耳其黄芪属植物的大部分二萜类化合物都具有正烯骨架,其中以线状醇、黄芪醇、7-外花心二醇和黄芪二醇为主要化合物。特别地,labdane, pimarane和beyerene二萜仅在少数物种中被发现。在酚类和类黄酮方面,迄今为止仅对12种植物进行了研究,发现它们富含苯乙醇苷类和类黄酮苷类。在活性方面,大多数物种的抗氧化活性测试,其次是抗菌和抗溃疡/抗炎活性。它们的细胞毒性、酶抑制、抗感染性和抗应激活性研究较少。结论:在上呼吸道和溃疡/炎症性疾病的治疗中,黄疸属应被视为有前景的治疗药物。
Chemical profile of the Anatolian Sideritis species with bioactivity studies.
Context: The genus Sideritis L. (Lamiaceae) is represented by 46 species in Turkey with an 79% endemism ratio, 42 of 46 belonging to the section Empodoclia.
Objective: In this review article, Sideritis species growing in Turkey have been evaluated for phytochemical constituents and biological activities.
Methods: The data for the isolates, components and extracts of the Anatolian Sideritis species and their bioactivity studies were retrieved from the main databases WoS, Scopus and PubMed from 1975 until 31 December 2022.
Results: In this review article, terpenoids, flavonoids, phenolics and other secondary metabolites isolated from Turkish Sideritis species were reported. Anatolian Sideritis species, which primarily consist of monoterpenes and sesquiterpenes, were studied in detail. Sideritis plants are represented by 46 species in Turkey, and 25 of them were investigated for their diterpenoids through isolation or LC-MS studies. Most of the diterpenoids of Turkish Sideritis species have ent-kaurene skeleton, among them linearol, siderol, 7-epicandicandiol and sideridiol were found to be the main compounds. Exceptionally, labdane, pimarane and beyerene diterpenoids were only found in a few species. For phenolics and flavonoids, only 12 species were investigated until now, and they were found to be rich in phenylethanoid glycosides and flavonoid glycosides. In terms of activity, most of the species were tested for antioxidant activity, followed by antimicrobial and anti-ulcer/anti-inflammatory activities. Their cytotoxic, enzyme inhibitory, antinociceptive and antistress activities were less frequently studied.
Conclusions: Sideritis species should be considered promising therapeutic agents in the treatment of upper respiratory tract and ulcer/inflammatory diseases.
期刊介绍:
Pharmaceutical Biology will publish manuscripts describing the discovery, methods for discovery, description, analysis characterization, and production/isolation (including sources and surveys) of biologically-active chemicals or other substances, drugs, pharmaceutical products, or preparations utilized in systems of traditional medicine.
Topics may generally encompass any facet of natural product research related to pharmaceutical biology. Papers dealing with agents or topics related to natural product drugs are also appropriate (e.g., semi-synthetic derivatives). Manuscripts will be published as reviews, perspectives, regular research articles, and short communications. The primary criteria for acceptance and publication are scientific rigor and potential to advance the field.