巨细胞病毒在实体器官移植中的防治进展。

IF 6.1 3区医学 Q1 IMMUNOLOGY

Infectious disease clinics of North America Pub Date : 2023-11-20 DOI:10.1016/j.idc.2023.10.001

Kathleen M Doss, Madeleine R Heldman, Ajit P Limaye

{"title":"巨细胞病毒在实体器官移植中的防治进展。","authors":"Kathleen M Doss, Madeleine R Heldman, Ajit P Limaye","doi":"10.1016/j.idc.2023.10.001","DOIUrl":null,"url":null,"abstract":"The authors summarize recent updates in the prevention and management of cytomegalovirus (CMV) in solid organ transplant (SOT) recipients with a focus on CMV seronegative recipients of organs from seropositive donors (CMV D+/R-) who are at highest risk of CMV infection and disease. They discuss advantages of preemptive therapy for CMV disease prevention in CMV D+/R- liver transplant recipients, letermovir for CMV prophylaxis, and updates in the development of monoclonal antibodies and vaccines as immune-based preventative strategies. They review the roles of maribavir and virus-specific T cells for management of resistant or refractory CMV infection in SOT recipients.","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":6.1000,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102935/pdf/","citationCount":"0","resultStr":"{\"title\":\"Updates in Cytomegalovirus Prevention and Treatment in Solid Organ Transplantation.\",\"authors\":\"Kathleen M Doss, Madeleine R Heldman, Ajit P Limaye\",\"doi\":\"10.1016/j.idc.2023.10.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The authors summarize recent updates in the prevention and management of cytomegalovirus (CMV) in solid organ transplant (SOT) recipients with a focus on CMV seronegative recipients of organs from seropositive donors (CMV D+/R-) who are at highest risk of CMV infection and disease. They discuss advantages of preemptive therapy for CMV disease prevention in CMV D+/R- liver transplant recipients, letermovir for CMV prophylaxis, and updates in the development of monoclonal antibodies and vaccines as immune-based preventative strategies. They review the roles of maribavir and virus-specific T cells for management of resistant or refractory CMV infection in SOT recipients.\",\"PeriodicalId\":13562,\"journal\":{\"name\":\"Infectious disease clinics of North America\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2023-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102935/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectious disease clinics of North America\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.idc.2023.10.001\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious disease clinics of North America","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.idc.2023.10.001","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

作者总结了实体器官移植(SOT)受者巨细胞病毒(CMV)预防和管理的最新进展，重点是来自血清阳性供者的器官(CMV D+/R-)的巨细胞病毒血清阴性受者，他们有最高的巨细胞病毒感染和疾病风险。他们讨论了在CMV D+/R-肝移植受者中预防CMV疾病的先发制人治疗的优势，利特莫韦预防CMV的优势，以及单克隆抗体和疫苗作为免疫预防策略的最新进展。他们回顾了马里巴韦和病毒特异性T细胞在治疗SOT受体耐药或难治性巨细胞病毒感染中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Updates in Cytomegalovirus Prevention and Treatment in Solid Organ Transplantation.

The authors summarize recent updates in the prevention and management of cytomegalovirus (CMV) in solid organ transplant (SOT) recipients with a focus on CMV seronegative recipients of organs from seropositive donors (CMV D+/R-) who are at highest risk of CMV infection and disease. They discuss advantages of preemptive therapy for CMV disease prevention in CMV D+/R- liver transplant recipients, letermovir for CMV prophylaxis, and updates in the development of monoclonal antibodies and vaccines as immune-based preventative strategies. They review the roles of maribavir and virus-specific T cells for management of resistant or refractory CMV infection in SOT recipients.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Infectious disease clinics of North America 医学-传染病学

CiteScore

8.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Infectious Disease Clinics of North America updates you on the latest trends in the clinical diagnosis and management of patients with infectious diseases, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Each issue focuses on a single topic in infectious disease, including clinical microbiology, compromised host infections, gastrointestinal infections, global health, hepatitis, HIV/AIDS, hospital-acquired infections, travel medicine, infection control, bacterial infections, sexually transmitted diseases, urinary tract infections, and viral infections.