实验性心力衰竭患者自主神经功能的遥测长期评估。

IF 1.3 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Katharina Boden , Pailin Pongratanakul , Julia Vogel , Nicola Willemsen , Eva-Maria Jülke , Jakob Balitzki , Hanna Tinel , Hubert Truebel , Wilfried Dinh , Thomas Mondritzki
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引用次数: 0

摘要

尽管在治疗心力衰竭(HF)方面取得了医学进展,但死亡率仍然很高。研究表明,自主神经系统(ANS)的改变与心衰进展和死亡率增加有关。需要临床前模型来评估调节自主神经失衡的新疗法的有效性。然而,既没有标准模型,也没有建立诊断方法来连续测量交感和副交感神经流出。数字技术可能是实验HF模型中自主神经功能持续评估的可靠工具。beagle犬植入遥测装置和起搏器(n = 6)。心衰由心室起搏诱发。在基线、HF状态和恢复阶段连续测量心脏血流动力学、血浆儿茶酚胺和描述ANS的参数(心率变异性(HRV)、减速能力(DC)和压力反射敏感性(BRS))。起搏方案导致预期的心脏血流动力学下降。ANS功能的遥测评估显示,总功率、直流和心率恢复明显下降,而BRS没有明显影响。相比之下,反映交感神经活动的血浆儿茶酚胺仅在恢复阶段显著增加。在实验模型中,心衰背景下ANS的精确诊断变得越来越重要。到目前为止,这些模型已经显示出许多局限性。在这里,我们提出了自主神经功能在心衰进展的连续评估。我们可以通过HR和BP衍生参数证明高分辨率ANS测量的优势,因为在HF进展过程中可以早期检测到自主神经失衡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Telemetric long-term assessment of autonomic function in experimental heart failure

Despite medical advances in the treatment of heart failure (HF), mortality remains high. It has been shown that alterations of the autonomic-nervous-system (ANS) are associated with HF progression and increased mortality. Preclinical models are required to evaluate the effectiveness of novel treatments modulating the autonomic imbalance. However, there are neither standard models nor diagnostic methods established to measure sympathetic and parasympathetic outflow continuously. Digital technologies might be a reliable tool for continuous assessment of autonomic function within experimental HF models.

Telemetry devices and pacemakers were implanted in beagle dogs (n = 6). HF was induced by ventricular pacing. Cardiac hemodynamics, plasma catecholamines and parameter describing the ANS ((heart rate variability (HRV), deceleration capacity (DC), and baroreflex sensitivity (BRS)) were continuously measured at baseline, during HF conditions and during recovery phase.

The pacing regime led to the expected depression in cardiac hemodynamics. Telemetric assessment of the ANS function showed a significant decrease in Total power, DC, and Heart rate recovery, whereas BRS was not significantly affected. In contrast, plasma catecholamines, revealing sympathetic activity, showed only a significant increase in the recovery phase.

A precise diagnostic of the ANS in the context of HF is becoming increasingly important in experimental models. Up to now, these models have shown many limitations. Here we present the continuous assessment of the autonomic function in the progression of HF. We could demonstrate the advantage of highly resolved ANS measurement by HR and BP derived parameters due to early detection of an autonomic imbalance in the progression of HF.

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来源期刊
Journal of pharmacological and toxicological methods
Journal of pharmacological and toxicological methods PHARMACOLOGY & PHARMACY-TOXICOLOGY
CiteScore
3.60
自引率
10.50%
发文量
56
审稿时长
26 days
期刊介绍: Journal of Pharmacological and Toxicological Methods publishes original articles on current methods of investigation used in pharmacology and toxicology. Pharmacology and toxicology are defined in the broadest sense, referring to actions of drugs and chemicals on all living systems. With its international editorial board and noted contributors, Journal of Pharmacological and Toxicological Methods is the leading journal devoted exclusively to experimental procedures used by pharmacologists and toxicologists.
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