K Stepniakowski, M Lapiński, A Januszewicz, B Noszczyk, E Szczepańska-Sadowska
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引用次数: 0
摘要
本研究旨在探讨自发性高血压大鼠(SHR)与正常对照组(WKY)相比，抗利尿激素(AVP)的压力反应性是否发生改变。观察9只有意识、无节制自发性高血压(SHR)大鼠和11只正常Wistar Kyoto (WKY)大鼠长期静脉、动脉置管后，分别注射2.5、5.0和10.0 ng AVP (Calbiochem)静脉滴注后血压和心率的变化。引起血压显著升高和心率降低所需的阈值剂量在WKY中比在SHR中要低。在每个剂量水平下，WKY组的血压升高持续时间比SHR组长。无论从绝对值还是与血压升高的关系来看，WKY患者的心动过缓都比SHR患者严重。因此，结果显示，尽管有抑制性反射性心动过缓，SHR患者对中等剂量AVP的降压反应性降低。提示在SHR中AVP对血管系统的外周作用减弱。
Pressor responsiveness to vasopressin in spontaneously hypertensive rats.
The present study was designed to find out whether pressor responsiveness to vasopressin (AVP) is altered in spontaneously hypertensive rats (SHR) in comparison with their normotensive controls (WKY). Blood pressure and heart rate changes after injection of graded doses of 2.5, 5.0 and 10.0 ng of AVP (Calbiochem) i.v. were compared in 9 conscious, unrestrained spontaneously hypertensive (SHR) and 11 normotensive Wistar Kyoto (WKY) rats, chronically instrumented with venous and arterial catheters. The threshold dose necessary to elicit a significant increase in blood pressure and reduction of heart rate was lower in WKY than in SHR. At each dose level the blood pressure elevation persisted for a longer period in WKY than in SHR. Bradycardia was greater in WKY than in SHR both in absolute terms and in relation to the blood pressure increase. Thus, the results reveal diminished pressor responsiveness to moderate doses of AVP in SHR in spite of suppressed reflex bradycardia. It is suggested that the peripheral action of AVP on the vascular system is attenuated in SHR.
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