光致癌作用被部分光降解的对氨基苯甲酸溶液延缓。

Photo-dermatology Pub Date : 1989-12-01
H Flindt-Hansen, P Thune, C J Nielsen
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引用次数: 0

摘要

将对氨基苯甲酸(PABA)溶液暴露在飞利浦TL 40 W/12日光灯发出的紫外线(UV)辐射下,在27 J/cm2的照射下,估计其光降解程度约为40%。通过质谱分析和紫外光谱分析证实了产物的形成。在上述太阳灯每日紫外线照射前,将该溶液涂于无毛浅色小鼠的背部,持续30周。与未受保护的对照组相比,PABA预照射溶液显著延缓了肿瘤诱导时间,显著减少了鳞状细胞癌的数量。这种肿瘤延缓能力与使用未辐照的PABA时的效果没有显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Photocarcinogenesis is retarded by a partly photodegraded solution of para-aminobenzoic acid.

A solution of para-aminobenzoic acid (PABA) was exposed to ultraviolet (UV) radiation emitted from a Philips TL 40 W/12 sunlamp and the degree of photodegradation following an exposure of 27 J/cm2 was estimated to be approximately 40%. The formation of the photoproducts was confirmed by mass spectroscopy and UV spectroscopy. The solution was painted on the backs of hairless light-pigmented mice prior to daily UV irradiation by the above sunlamp, and this procedure was continued for 30 weeks. The preirradiated solution of PABA significantly retarded the tumor induction time and reduced significantly the number of squamous cell carcinomas compared with nonprotected controls. This tumor-retarding ability did not differ significantly from the effect achieved when using nonirradiated PABA.

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