双光子吸收法测定闭经妇女的骨密度。

Y K Soong, J J Hsu, K Y Tzen
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引用次数: 0

摘要

测定了17例性腺发育不良患者、21例卵巢早衰患者、14例高泌乳素血症患者、23例卵巢切除术后患者和41例正常健康妇女的骨密度(BMD)。根据是否接受雌激素替代疗法,每组被分为两个亚组。线性回归分析显示,正常健康女性腰椎骨密度以每年0.006 g/cm2的速度显著下降。每个研究组的个体值分布接近或在正常置信限内,性腺发育不良组除外。未进行雌激素替代治疗的各组平均骨密度明显低于对照组。卵巢早衰组和卵巢切除术后组闭经时间与骨密度值有显著相关性。这些结果表明,双光子吸收仪测量的骨密度在闭经患者中降低,特别是在性腺发育不良的患者中。雌激素替代疗法能够减轻骨质流失的严重程度,但不能增加骨量。双光子吸收测定法(DPA)是一种简单、有效、准确的评估骨质疏松严重程度和监测治疗效果的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Measurement of bone mineral density in amenorrheic women with dual photon absorptiometry.

Bone mineral density (BMD) was measured in 17 patients with gonadal dysgenesis, 21 patients with premature ovarian failure, 14 patients with hyperprolactinemia, 23 patients postoophorectomy and 41 normal healthy women. Each group was divided into two subgroups, on the basis of whether or not they were receiving estrogen replacement therapy. Linear regression analysis showed a significant loss of BMD at a rate of 0.006 g/cm2 per year in the lumbar spine of normal healthy women. The distribution of individual values in each study group was near or within normal confidence limits, except for the group with gonadal dysgenesis. The mean BMD of each group without estrogen replacement therapy was significantly less than that of the control group. There was a significant correlation between the duration of amenorrhea and BMD values in the groups with premature ovarian failure and postoophorectomy. These results indicate that BMD, measured by dual photon absorptiometry, was reduced in amenorrheic patients, especially in patients with gonadal dysgenesis. Estrogen replacement therapy was able to decrease the severity of bone loss, but failed to increase the bone mass. Dual photon absorptiometry (DPA) is a simple, effective, and accurate tool for assessing the severity of osteoporosis and monitoring the effect of therapy.

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