肝病患者体外生物转化的研究。

Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1989-01-01

J Truckenbrodt, H Kraul, G Machnik, R Volland, A Hoffmann

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引用次数: 0

摘要

测定了53例慢性肝病患者肝组织中7-乙氧基香豆素o -去乙基酶(ECOD)的活性。值得注意的是，与组织学正常或残余肝炎患者相比，肝病、慢性肝炎和肝硬化患者的ECOD值较低。慢性肝炎和肝硬化患者的ECOD活性下降与实质坏死、结节性肝转化和肝内纤维化有关。目前还不可能给出一个令人满意的解释，降低ECOD活性的肝脏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Studies on the in-vitro biotransformation in patients with liver diseases.

The activity of 7-ethoxycoumarin O-deethylase (ECOD) was determined in the human liver bioptate of 53 patients with chronic liver diseases. Remarkable are the lower values of ECOD in the hepatoses, chronic hepatitis and cirrhosis as compared to patients with normal histology or residual hepatitis. The decline in the activity of ECOD in the patients with chronic hepatitis and cirrhosis has to be seen in connection with parenchymatous necrosis, nodular liver transformation and intracinar fibrosis. For the time being it is not possible to give a satisfactory explanation of the decrease in the ECOD activity of the hepatoses.

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Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR

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