UVA窄带辐射与UVB窄带辐射对日本受试者红斑反应的相互作用。

Photo-dermatology Pub Date : 1989-10-01
Y Kurumaji, Y Satoh
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引用次数: 0

摘要

采用窄带辐射研究了紫外线A (UVA)和紫外线B (UVB)对24名日本健康志愿者背部皮肤红斑反应的相互作用。测定了UVA (MEDB)和UVA (MEDA)的最小红斑剂量(MED),并将UVA和UVB同时应用于同一部位,同时进行2次暴露(A + B, B + A)。在实验1中,研究了UVA和UVB的亚致红剂量对产生可见红斑的相互作用;在三种不同剂量(1,2.4和4.9 J/cm2)的UVA照射下,MEDA和MEDB的分数之和最多等于1。这种相互作用被认为是光附加作用。在实验2中,固定剂量的UVB(每个受试者1.7 MEDB)与4种不同剂量的UVA (1,2.4, 4.9, 7.4 J/cm2)联合使用;将该红斑反应与单独由UVB引起的红斑分级表进行比较,并给予1 ~ 7分。计算每个组合照射的MED总照射数,并将其得分与基于MED数的期望得分进行比较。A + B的得分与期望值基本吻合,而B + A的得分明显小于期望值。这表明在明亮红斑剂量范围内,A + B的光增加和B + A的光恢复。研究了日本皮肤类型(JST)与波段相互作用的关系。在实验2中,当UVA照射后再进行UVB照射时,JST III组受试者对高剂量UVA表现出光恢复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The interaction between narrow-band radiation of UVA and that of UVB on erythemal reaction in Japanese subjects.

The interaction between ultraviolet A (UVA) and ultraviolet B (UVB) on erythemal reaction was investigated on the skin of the backs of 24 healthy Japanese volunteers, using narrow-band radiation. The minimal erythema doses (MED) for UVB (MEDB) and UVA (MEDA) were determined and UVA and UVB were both applied to the same site in immediate combination with 2 orders of exposure (A + B, B + A). In experiment 1 the interaction between suberythemogenic doses of UVA and UVB to produce a visible erythema was examined; the sum of the fraction of MEDA and the fraction of MEDB was at most equal to 1 for 3 different doses of UVA (1, 2.4, 4.9 J/cm2) with either order of exposure. This interaction is considered to be photoaddition. In experiment 2 a fixed dose of UVB (1.7 MEDB of each subject) was applied in combination with 4 different doses of UVA (1, 2.4, 4.9, 7.4 J/cm2); the erythemal reaction was compared with the grading scale erythema produced by UVB alone and allotted a score of 1 to 7. The total number of MED irradiated was calculated for each combination exposure and the score obtained was compared with the score expected on the basis of that number of MED. The scores for A + B practically coincided with the expected values, whereas those for B + A were decidedly smaller than the expected values. This suggests photoaddition for A + B and photorecovery for B + A in the bright erythema dose range. The relationship between the Japanese skin type (JST) and the waveband interaction was also examined. In experiment 2, when UVA irradiation was followed by UVB, the subjects in JST group III showed photorecovery for high-dose UVA.

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