[PUVA移植调理结合受体环孢素治疗延长大鼠同种异体心肾移植存活时间]。

Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR Pub Date : 1989-01-01

H Oesterwitz, J Kaden, W Schneider, R Schirrow

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摘要

环孢素(CsA)的剂量-反应研究证实，在第0天给药2mg kg体重对大鼠肾移植是次优治疗值。将经PUVA处理的心脏和肾脏同种异体移植物移植到临时CsA免疫抑制受体中，与单独使用PUVA相比，移植物存活率进一步提高。PUVA + CsA与PUVA治疗的同种异体移植物永久存活的比例分别为40 vs 18%(心脏)和70 vs 40%(肾脏)。因此，PUVA预处理和低剂量CsA治疗对大鼠移植心脏和肾脏的生存具有协同作用。

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[Extending the survival time of allogenic heart and kidney transplants in the rat by a combination of PUVA transplant conditioning and cyclosporin treatment of the recipient].

Dose-response studies of cyclosporin (CsA) established that a dose of 2 mg kg body weight on day 0 was of therapeutic suboptimal value in rat kidney allotransplantation. When PUVA-treated heart and kidney allografts were transplanted into temporary CsA immunosuppressed recipients the graft survival rates were further improved as compared with PUVA alone. Forty vs. 18% (heart) and 70 vs. 40% (kidney) of the PUVA + CsA vs. PUVA treated allografts survived permanently. Therefore a synergistic effect of PUVA pretreatment and low-dose CsA therapy on rat heart and renal allograft survival was demonstrated.

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Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR

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